Zhao Han, Guo Shicheng, Liu Jie, Li Li, Wu Jing
Immunization Program Institute, Jiangxi Provincial Key Laboratory of Major Epidemic Prevention and Control, Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, Jiangxi Province, China.
School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Medicine (Baltimore). 2025 May 30;104(22):e42597. doi: 10.1097/MD.0000000000042597.
The aim of this study was to explore factors influencing pneumococcal vaccination in people aged ≥ 60 years. We used a non-matched case-control study design to collect data on PPSV23 administration and pneumococcal disease/PPSV23 cognition and other factors among ≥ 60-year-olds in 2 prefectures of Jiangxi Province from January 2022 to December 2023. We compared the composition of each factor between vaccinated and non-vaccinated subjects, identified factors influencing pneumococcal vaccination using a logistic regression model and evaluated the model predictive ability by using ROC curve. This study included 212 subjects who received PPSV23 and 213 subjects who did not receive. The analysis of knowledge and attitude of pneumococcal disease/PPSV23 showed that the proportion of awareness ranged from 13.21% to 84.43% in the vaccinated group and from 13.62% to 67.14% in the unvaccinated group, and the proportion of positive attitudes ranged from 39.15% to 89.15% in the vaccinated group and 30.52% to 63.38% in the unvaccinated group. Multivariate stepwise logistic regression analysis showed that urban residents (aOR = 2.603, 95% CI: 1.236-5.481), PPSV23 vaccination history of surrounding people (aOR = 8.152, 95% CI: 4.832-13.751), healthcare workers recommended PPSV23 (aOR = 2.960, 95% CI: 1.763-4.968), acceptable vaccine price at ≥ 200 yuan (aOR = 3.061, 95% CI: 1.461-6.412), and positive attitude toward pneumococcal disease/PPSV23 (aOR = 4.636, 95% CI: 1.492-14.411) promoted PPSV23 vaccination of subjects. The pneumococcal vaccination of ≥ 60-year-olds in Jiangxi was mainly influenced by PPSV23 vaccination history of surrounding people, pneumococcal disease/PPSV23 cognition, and vaccine price. It is suggested that health education on knowledge about pneumococcal disease/PPSV23 be strengthened for the elderly.
本研究旨在探讨影响60岁及以上人群接种肺炎球菌疫苗的因素。我们采用非匹配病例对照研究设计，收集了2022年1月至2023年12月江西省2个地区60岁及以上人群中23价肺炎球菌多糖疫苗（PPSV23）接种情况、肺炎球菌疾病/PPSV23认知及其他因素的数据。我们比较了接种组和未接种组各因素的构成情况，使用逻辑回归模型确定影响肺炎球菌疫苗接种的因素，并通过ROC曲线评估模型预测能力。本研究纳入了212名接种PPSV23的受试者和213名未接种的受试者。肺炎球菌疾病/PPSV23知识与态度分析显示，接种组知晓率为13.21%至84.43%，未接种组为13.62%至67.14%；接种组积极态度比例为39.15%至89.15%，未接种组为30.52%至63.38%。多因素逐步逻辑回归分析显示，城镇居民（调整后比值比[aOR]=2.603，95%置信区间[CI]：1.236 - 5.481）、周围人群PPSV23接种史（aOR = 8.152，95% CI：4.832 - 13.751）、医护人员推荐PPSV23（aOR = 2.960，95% CI：1.763 - 4.968）、可接受200元及以上疫苗价格（aOR = 3.061，95% CI：1.461 -
