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Zavegepant用于偏头痛急性治疗的临床评估。

Clinical evaluation of zavegepant for the acute treatment of migraine.

作者信息

Fan Huiqiao, Wadolowski Janette, Shan Ryan, Contrera Gianni J, Polomoff Christina M

机构信息

University of Connecticut School of Pharmacy, Storrs.

出版信息

J Manag Care Spec Pharm. 2025 Jun;31(6):598-602. doi: 10.18553/jmcp.2025.31.6.598.

DOI:10.18553/jmcp.2025.31.6.598
PMID:40443004
Abstract

Zavegepant is the first intranasal calcitonin gene-related peptide receptor antagonist approved for the acute treatment of migraine and offers a new nonoral option for patients. This article reports the findings of a comprehensive literature review to assess zavegepant's safety and effectiveness. Evidence synthesis involved reporting findings from clinical trials and evaluating comparative effectiveness. This review was prepared by the University of Connecticut School of Pharmacy Academy of Managed Care Pharmacy (AMCP) Student Chapter. The student author group won the AMCP National Pharmacy and Therapeutics competition for their zavegepant product review in March 2024.

摘要

扎维吉泮是首个获批用于偏头痛急性治疗的鼻内降钙素基因相关肽受体拮抗剂,为患者提供了一种新的非口服选择。本文报告了一项全面文献综述的结果,以评估扎维吉泮的安全性和有效性。证据综合包括报告临床试验结果和评估比较有效性。本综述由康涅狄格大学药学院管理式医疗药学学会(AMCP)学生分会编写。学生作者团队因其在2024年3月对扎维吉泮的产品综述而赢得了AMCP全国药学与治疗学竞赛。

相似文献

1
Clinical evaluation of zavegepant for the acute treatment of migraine.Zavegepant用于偏头痛急性治疗的临床评估。
J Manag Care Spec Pharm. 2025 Jun;31(6):598-602. doi: 10.18553/jmcp.2025.31.6.598.
2
Intranasal zavegepant for the acute treatment of migraine.用于偏头痛急性治疗的鼻腔内给药的zavegepant。
Expert Rev Neurother. 2024 Dec;24(12):1131-1140. doi: 10.1080/14737175.2024.2405741. Epub 2024 Sep 23.
3
The efficacy and safety of zavegepant nasal inhalation versus oral calcitonin-gene related peptide receptor antagonists in the acute treatment of migraine: a systematic review and network meta-analysis of the literature.在偏头痛急性治疗中,扎韦普坦鼻内吸入剂与口服降钙素基因相关肽受体拮抗剂的疗效与安全性:一项系统评价及文献网络荟萃分析
J Headache Pain. 2025 Mar 10;26(1):48. doi: 10.1186/s10194-025-01984-7.
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Long-term safety of zavegepant nasal spray for the acute treatment of migraine: A phase 2/3 open-label study.扎那米韦鼻喷剂治疗偏头痛急性发作的长期安全性:一项 2/3 期开放标签研究。
Cephalalgia. 2024 Aug;44(8):3331024241259456. doi: 10.1177/03331024241259456.
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Clin Neuropharmacol. 2024;47(3):72-81. doi: 10.1097/WNF.0000000000000588.
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本文引用的文献

1
The efficacy and safety of zavegepant nasal inhalation versus oral calcitonin-gene related peptide receptor antagonists in the acute treatment of migraine: a systematic review and network meta-analysis of the literature.在偏头痛急性治疗中,扎韦普坦鼻内吸入剂与口服降钙素基因相关肽受体拮抗剂的疗效与安全性:一项系统评价及文献网络荟萃分析
J Headache Pain. 2025 Mar 10;26(1):48. doi: 10.1186/s10194-025-01984-7.
2
Effects of multiple-dose administration of zavegepant nasal spray on the single-dose pharmacokinetics of ethinyl estradiol-levonorgestrel.扎韦潘坦鼻喷雾剂多剂量给药对炔雌醇-左炔诺孕酮单剂量药代动力学的影响。
Headache. 2025 Jan;65(1):14-23. doi: 10.1111/head.14863. Epub 2024 Nov 5.
3
Reduced hepatic impairment study to evaluate pharmacokinetics and safety of zavegepant and to inform dosing recommendation for hepatic impairment.
降低肝损伤研究,以评估扎韦潘坦的药代动力学和安全性,并为肝损伤患者的给药建议提供依据。
Clin Transl Sci. 2024 Jul;17(7):e13813. doi: 10.1111/cts.13813.
4
Concentration-QTc and cardiac safety analysis of single and multiple zavegepant nasal spray doses in healthy participants to support approval.单次和多次依他佐辛鼻喷剂给药在健康受试者中的浓度-QTc 和心脏安全性分析,以支持批准。
CPT Pharmacometrics Syst Pharmacol. 2024 Jun;13(6):1044-1054. doi: 10.1002/psp4.13140. Epub 2024 May 29.
5
Calcitonin gene-related peptide-targeting therapies are a first-line option for the prevention of migraine: An American Headache Society position statement update.降钙素基因相关肽靶向治疗是预防偏头痛的一线选择:美国头痛学会立场声明更新。
Headache. 2024 Apr;64(4):333-341. doi: 10.1111/head.14692. Epub 2024 Mar 11.
6
Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis.鼻腔给药治疗偏头痛急性发作的疗效和安全性:系统评价和网络荟萃分析。
J Headache Pain. 2023 Sep 18;24(1):129. doi: 10.1186/s10194-023-01662-6.
7
Safety and Efficacy of Zavegepant in Treating Migraine: A Systematic Review.扎韦普坦治疗偏头痛的安全性和有效性:一项系统评价
Cureus. 2023 Jul 17;15(7):e41991. doi: 10.7759/cureus.41991. eCollection 2023 Jul.
8
Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial.美国一项 zavegepant 10 mg 鼻喷制剂用于偏头痛急性治疗的安全性、耐受性和疗效的 3 期、双盲、随机、安慰剂对照多中心试验。
Lancet Neurol. 2023 Mar;22(3):209-217. doi: 10.1016/S1474-4422(22)00517-8.
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Zavegepant nasal spray for the acute treatment of migraine: A Phase 2/3 double-blind, randomized, placebo-controlled, dose-ranging trial.瑞美吉泮鼻喷雾剂治疗偏头痛的急性发作:一项 2/3 期双盲、随机、安慰剂对照、剂量范围研究。
Headache. 2022 Oct;62(9):1153-1163. doi: 10.1111/head.14389. Epub 2022 Oct 14.
10
Improving distress perception and mutuality in migraine caregivers after 6 months of galcanezumab treatment.戈卡那肽治疗偏头痛照料者 6 个月后,改善其痛苦感知和相互性。
Headache. 2022 Oct;62(9):1143-1147. doi: 10.1111/head.14400. Epub 2022 Oct 7.