Giannakopoulos Kostis, Lambrou Persefoni, Kaklamanos Eleftherios G, Christodoulou Maria Nefeli
School of Dentistry, European University Cyprus, 6 Diogenes str, 2404 Engomi, Nicosia, Cyprus.
Scientific Collaborator, School of Dentistry, European University Cyprus, 6 Diogenes str, 2404 Engomi, Nicosia, Cyprus.
Oxf Med Case Reports. 2025 May 28;2025(5):omaf042. doi: 10.1093/omcr/omaf042. eCollection 2025 May.
Darier disease is a rare autosomal dominant inherited skin disorder, caused by mutations in the ATP2A2 gene. Oral manifestations can include mucosal lesions, salivary gland involvement, and xerostomia, that can significantly increase the risk of dental caries. A 58-year-old female with a confirmed diagnosis of Darier disease presented with oral manifestations, including recurrent sublingual blisters, xerostomia, and carious lesions. The intraoral examination revealed white spot carious lesions and cavitated caries, particularly in the cervical areas of several teeth. Dental treatment included fluoride mouthrinse, oral hygiene instructions, and restorative care for the cavitated teeth. The patient was also advised on preventive and symptomatic measures for xerostomia. Dentists should be aware of these potential issues and provide appropriate preventive, etiologic and symptomatic care. Regular follow-ups are essential to monitor the progression of dental lesions and manage oral health in patients with Dd.
毛囊角化病是一种罕见的常染色体显性遗传性皮肤病，由ATP2A2基因突变引起。口腔表现可包括黏膜病变、唾液腺受累和口干，这会显著增加患龋齿的风险。一名确诊为毛囊角化病的58岁女性出现口腔表现，包括复发性舌下水泡、口干和龋损。口腔检查发现白斑龋损和龋洞，特别是在几颗牙齿的颈部区域。牙科治疗包括含氟漱口水、口腔卫生指导以及对有龋洞牙齿的修复治疗。还建议患者采取口干的预防和对症措施。牙医应了解这些潜在问题，并提供适当的预防、病因和对症护理。定期随访对于监测牙病进展和管理毛囊角化病患者的口腔健康至关重要。
