Mwingwa Anthon, Shangali Aminiel, Niccodem Elieshiupendo, Dewji Sabah, Sillas Sandra, Joachim Agricola, Majigo Mtebe
Department of Microbiology and Immunology, Kilimanjaro Christian Medical University College, Longuo Street, Moshi Urban District, Tanzania.
Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Kalenga Street, Upanga West, Ilala District, Dar es Salaam, Tanzania.
Oxf Med Case Reports. 2025 May 28;2025(5):omaf052. doi: 10.1093/omcr/omaf052. eCollection 2025 May.
A 53-year-old man developed a surgical site infection after undergoing a pylorus-preserving pancreaticoduodenectomy despite receiving preventive antibiotics. The infection was linked to , a rare and multidrug-resistant gram-negative bacterium from the Enterobacterales order, which mainly affects immunocompromised individuals. Identifying the pathogen proved challenging; standard biochemical tests did not provide conclusive results, necessitating the use of the Analytical Profile Index and a specialized biochemical panel for Enterobacterales. This case marks the first documented occurrence of multidrug-resistant causing a surgical site infection in Tanzania. It underscores the rising presence of uncommon pathogens in healthcare settings and emphasizes the need for enhanced diagnostic methods and infection control strategies, especially in resource-limited environments where antibiotic resistance presents significant challenges.
一名53岁男性在接受保留幽门的胰十二指肠切除术后，尽管使用了预防性抗生素，仍发生了手术部位感染。感染与一种罕见的、耐多药的肠杆菌目革兰氏阴性菌有关，这种细菌主要影响免疫功能低下的个体。鉴定病原体具有挑战性；标准生化试验未提供确凿结果，因此需要使用分析谱指数和专门的肠杆菌生化检测板。该病例是坦桑尼亚首例有记录的耐多药菌引起手术部位感染的病例。它突显了医疗机构中不常见病原体的日益增多，并强调需要加强诊断方法和感染控制策略，特别是在抗生素耐药性带来重大挑战的资源有限环境中。
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