Ji Cheng, Ji Lingjia, Wang Fei, Zhang Anping, Shen Liang
Department of Thoracic and Cardiac Surgery, Nantong First People's Hospital, Nantong, Jiangsu, 226000, China.
Nursing Group, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226000, China.
Open Med (Wars). 2025 May 27;20(1):20241127. doi: 10.1515/med-2024-1127. eCollection 2025.
This study explores the factors related to the expression levels of carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) and their association with poor postoperative prognosis in patients with esophageal squamous cell carcinoma (ESCC) who underwent minimally invasive resection.
Eighty patients with ESCC who underwent minimally invasive surgery were divided into two groups: 40 with poor prognosis (recurrence) and 40 with good prognosis (no recurrence). Additionally, 80 healthy subjects were selected as a control group. Serum CA199 and CEA levels were measured before surgery and 3 and 6 months postoperatively.
The serum CA199 and CEA levels in the experimental group were significantly higher than in the control group ( < 0.05). Patients with poor prognoses within the experimental group had higher CA199 and CEA levels than those with good prognoses ( < 0.05). In the poor prognosis group, CA199 and CEA levels at 6 months were significantly higher than at 3 months post-surgery ( < 0.05).
Poor prognosis in ESCC patients after minimally invasive resection may be influenced by factors such as lymph node metastasis, lesion length, and tumor location. Elevated CA199 and CEA levels postoperatively can serve as predictors of poor prognosis in patients with ESCC.
本研究探讨与接受微创切除的食管鳞状细胞癌（ESCC）患者碳水化合物抗原199（CA199）和癌胚抗原（CEA）表达水平相关的因素及其与术后不良预后的关联。
将80例行微创手术的ESCC患者分为两组：40例预后差（复发）组和40例预后好（无复发）组。另外，选取80名健康受试者作为对照组。于术前及术后3个月和6个月测量血清CA199和CEA水平。
实验组血清CA199和CEA水平显著高于对照组（<0.05）。实验组中预后差的患者CA199和CEA水平高于预后好的患者（<0.05）。在预后差的组中，术后6个月的CA199和CEA水平显著高于术后3个月（<0.05）。
ESCC患者微创切除术后预后差可能受淋巴结转移、病变长度和肿瘤位置等因素影响。术后CA199和CEA水平升高可作为ESCC患者预后差的预测指标。
