Studies on beta-lactam antibiotics VIII. Structure-activity relationships of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem- 4-carboxylic acids.
作者信息
Yamanaka H, Takasugi H, Masugi T, Kochi H, Miyai K, Takaya T
出版信息
J Antibiot (Tokyo). 1985 Aug;38(8):1068-76. doi: 10.7164/antibiotics.38.1068.
PMID:4044407
Abstract
The synthesis, antimicrobial activity and oral absorptivity of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem-4- carboxylic acids are described. The [(Z)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyimino]acetyl group was selected as the most suitable 7-substituent from seven 7-acyl groups for our further investigation of orally active cephalosporins.
摘要
相似文献
1
Studies on beta-lactam antibiotics VIII. Structure-activity relationships of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem- 4-carboxylic acids.
J Antibiot (Tokyo). 1985 Aug;38(8):1068-76. doi: 10.7164/antibiotics.38.1068.
2
Studies on beta-lactam antibiotics. X. Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamido] cephalosporin derivatives.β-内酰胺抗生素的研究。十、7β-[(Z)-2-(2-氨基-4-噻唑基)-2-(羧基甲氧基亚氨基)乙酰胺基]头孢菌素衍生物的合成及构效关系
J Antibiot (Tokyo). 1986 Jan;39(1):101-10. doi: 10.7164/antibiotics.39.101.
3
Studies on beta-lactam antibiotics. I. Synthesis and in vitro anti-pseudomonal activity of 3-isothiazole-cephalosporin derivatives.β-内酰胺类抗生素的研究。I. 3-异噻唑头孢菌素衍生物的合成及其体外抗假单胞菌活性
J Antibiot (Tokyo). 1987 Feb;40(2):173-81. doi: 10.7164/antibiotics.40.173.
4
Studies on beta-lactam antibiotics. IV. Structure-activity relationships of 7 beta-[(Z)-2-alkoxyimino-2-(2-amino-4-thiazolyl)acetamido]-3-cephem-4-carboxylic acids.β-内酰胺类抗生素的研究。IV. 7β-[(Z)-2-烷氧基亚氨基-2-(2-氨基-4-噻唑基)乙酰胺基]-3-头孢烯-4-羧酸的构效关系
J Antibiot (Tokyo). 1981 Oct;34(10):1357-9. doi: 10.7164/antibiotics.34.1357.
5
Studies on beta-lactam antibiotics. III. Synthesis and enzymatic stability of 3-acyloxymethyl-7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acids.β-内酰胺类抗生素的研究。III. 3-酰氧基甲基-7β-[(Z)-2-(2-氨基-4-噻唑基)-2-(甲氧基亚氨基)乙酰胺基]-3-头孢烯-4-羧酸的合成及酶稳定性
J Antibiot (Tokyo). 1981 Oct;34(10):1300-10. doi: 10.7164/antibiotics.34.1300.
6
Studies on cephalosporin antibiotics. IV. Synthesis, antibacterial activity and oral absorption of new 3-(2-substituted-vinylthio)-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2- (carboxymethoxyimino)acetamido]cephalosporins.
J Antibiot (Tokyo). 1991 Dec;44(12):1422-31. doi: 10.7164/antibiotics.44.1422.
7
Studies on cephalosporin antibiotics. III. Synthesis, antibacterial activity and oral absorption of new 3-(substituted-alkylthio)-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2- (carboxymethoxyimino)acetamido]cephalosporins.
J Antibiot (Tokyo). 1991 May;44(5):498-506. doi: 10.7164/antibiotics.44.498.
8
Oral absorption of cephalosporin antibiotics. 3. Synthesis and biological properties of 7 alpha-methoxy-7 beta-(arylacetamido)-3-chloro-3-cephem-4- carboxylic acids.头孢菌素类抗生素的口服吸收。3. 7α-甲氧基-7β-（芳基乙酰胺基）-3-氯-3-头孢烯-4-羧酸的合成及生物学性质
J Med Chem. 1988 Oct;31(10):1997-2000. doi: 10.1021/jm00118a024.
9
Studies on beta-lactam antibiotics. XIX. Structure-activity relationships of cephalosporins having a thiadiazolylthiomethyl group at the C-3 side chain.
J Antibiot (Tokyo). 1991 May;44(5):507-16. doi: 10.7164/antibiotics.44.507.
引用本文的文献
1
SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3.铜绿假单胞菌PBP3的铁载体共轭单氨基甲酸盐抑制剂的构效关系及结构分析
ACS Med Chem Lett. 2015 Mar 22;6(5):537-42. doi: 10.1021/acsmedchemlett.5b00026. eCollection 2015 May 14.
Zotero 插件