Studies on beta-lactam antibiotics VIII. Structure-activity relationships of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem- 4-carboxylic acids.
作者信息
Yamanaka H, Takasugi H, Masugi T, Kochi H, Miyai K, Takaya T
出版信息
J Antibiot (Tokyo). 1985 Aug;38(8):1068-76. doi: 10.7164/antibiotics.38.1068.
PMID:4044407
Abstract
The synthesis, antimicrobial activity and oral absorptivity of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem-4- carboxylic acids are described. The [(Z)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyimino]acetyl group was selected as the most suitable 7-substituent from seven 7-acyl groups for our further investigation of orally active cephalosporins.
摘要
Zotero 插件