Guo Rongqi, Wang Rui, Zhang Weisong, Li Yangyang, Wang Yihao, Wang Hao, Li Xia, Song Jianxiang
Department of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Department of General Medicine, Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng, Jiangsu 224000, P.R. China.
Int J Mol Med. 2025 Jul;56(1). doi: 10.3892/ijmm.2025.5554. Epub 2025 May 30.
The early growth response (EGR) family comprises four zinc finger transcription factors: EGR1, EGR2, EGR3 and EGR4. These transcription factors belong to the Cys‑His‑type zinc finger protein family and are essential in cell differentiation, proliferation, apoptosis and stress response. Initially, EGR1 was recognised for its essential regulatory role in tumourigenesis. Recent studies have identified similarities between other members of the EGR family and EGR1 in tumour regulation and the multifaceted regulatory mechanism employed by the EGR family to affect tumours. Therefore, the present review describes the dual roles of the EGR family in tumours and their regulatory mechanisms in immunity, metabolism and differentiation. Additionally, the present review offers a new perspective on relevant tumour therapeutic studies based on current EGR targeting.
早期生长反应（EGR）家族由四种锌指转录因子组成：EGR1、EGR2、EGR3和EGR4。这些转录因子属于半胱氨酸-组氨酸型锌指蛋白家族，在细胞分化、增殖、凋亡和应激反应中至关重要。最初，EGR1因其在肿瘤发生中的重要调节作用而被认可。最近的研究已经确定了EGR家族其他成员与EGR1在肿瘤调节方面的相似性，以及EGR家族影响肿瘤所采用的多方面调节机制。因此，本综述描述了EGR家族在肿瘤中的双重作用及其在免疫、代谢和分化中的调节机制。此外，本综述基于当前对EGR的靶向作用，为相关肿瘤治疗研究提供了新的视角。
