Kantanen Saija, Räsänen Kati, Kolho Kaija-Leena, Huhtala Heini, Sipilä Kalle, Pörsti Ilkka, Vekara Laura, Piippo-Savolainen Eija, Lakka Timo, Arikoski Pekka, Hiltunen Pauliina
Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
Kuopio Pediatric Research Unit, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
J Pediatr Gastroenterol Nutr. 2025 Aug;81(2):275-285. doi: 10.1002/jpn3.70091. Epub 2025 May 30.
There are only a few studies on physical fitness in pediatric inflammatory bowel disease (PIBD). We compared physical fitness in PIBD patients versus healthy controls and analyzed the role of contributing disease- and patient-related factors.
This cross-sectional study included 73 patients with PIBD aged 13.0 (2.8) (mean [standard deviation]) years from two Finnish university hospitals, 31 with Crohn's disease and 42 with ulcerative or unclassified colitis, and 74 age- and sex-matched controls. Cardiorespiratory and neuromuscular fitness were assessed, physical activity (PA) was measured, and disease characteristics concerning physical fitness were analyzed.
Cardiorespiratory fitness, that is, maximal workload (W/kg) and peak oxygen uptake (VOpeak/kg) were lower in patients with PIBD than in controls: W/kg 3.01 (0.72) versus 3.29 (0.57) W/kg, p = 0.007; VOpeak/kg 38.3 (8.5) versus 46.9 (7.4) mL/kg/min, p < 0.001, respectively. Neuromuscular fitness, as evaluated using sit-up, standing long jump, grip strength, and shuttle run tests, was lower in patients compared with controls. Disease activity, severity, and duration, or PA, were not related to W/kg and VOpeak/kg in univariate analysis. However, in multivariate analysis, the use of biological medications was associated positively, and higher age- and sex-adjusted body mass index for children and adolescents was associated negatively with W/kg and VOpeak/kg.
Patients with PIBD had lower physical fitness than age- and sex-matched controls. The causes of lower physical fitness in PIBD are likely complex, warranting the need for longitudinal studies examining the associations of factors like body composition, visceral fat, and control of disease severity with physical fitness.
关于儿童炎症性肠病（PIBD）体能的研究较少。我们比较了PIBD患者与健康对照者的体能，并分析了疾病相关因素和患者相关因素的作用。
这项横断面研究纳入了来自芬兰两家大学医院的73例年龄为13.0（2.8）（均值[标准差]）岁的PIBD患者，其中31例为克罗恩病患者，42例为溃疡性或未分类结肠炎患者，以及74例年龄和性别匹配的对照者。评估了心肺功能和神经肌肉功能，测量了身体活动（PA），并分析了与体能相关的疾病特征。
PIBD患者的心肺功能，即最大工作量（W/kg）和峰值摄氧量（VOpeak/kg）低于对照者：W/kg分别为3.01（0.72）与3.29（0.57）W/kg，p = 0.007；VOpeak/kg分别为38.3（8.5）与46.9（7.4）mL/kg/min，p < 0.001。通过仰卧起坐、立定跳远、握力和往返跑测试评估的神经肌肉功能，患者低于对照者。在单因素分析中，疾病活动度、严重程度和病程或PA与W/kg和VOpeak/kg无关。然而，在多因素分析中，生物药物的使用呈正相关，儿童和青少年经年龄和性别调整的较高体重指数与W/kg和VOpeak/kg呈负相关。
PIBD患者的体能低于年龄和性别匹配的对照者。PIBD患者体能较低的原因可能很复杂，因此有必要进行纵向研究，以探讨身体成分、内脏脂肪和疾病严重程度控制等因素与体能之间的关联。
