一项焦点小组研究，旨在评估肠易激综合征患者对人乳寡糖的看法及生活方式见解。
A focus group study to assess perspectives of patients with irritable bowel syndrome on human milk oligosaccharides and lifestyle insights.
作者信息
Morales Patricia Sanz, Wijeyesekera A, Robertson M D, Kennedy J, Major G, Boulangé C L, Gibson G R
机构信息
Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, Berkshire, RG6 6AH, UK.
Department of Nutrition, Food and Exercise Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK.
出版信息
Eur J Nutr. 2025 May 30;64(5):196. doi: 10.1007/s00394-025-03719-5.
OBJECTIVE
To explore the impact of Irritable Bowel Syndrome (IBS) on quality of life (QoL) measures, with specific focus on symptoms experienced and their impact upon diet, lifestyle, and mood. Insights into triggers of IBS flare-ups and the potential barriers to the use of prebiotics, in particular human milk oligosaccharides (HMOs), will be used to inform the design of a prospective human dietary intervention trial.
METHOD
Five virtual focus groups were held between March 2022 and January 2023. Thirteen females and eleven males were recruited around Berkshire, UK and through social media to attend a single, same-sex focus group. Thematic analysis of transcripts was undertaken. Themes were organised using a semantic coding tree.
RESULTS
Low QoL in IBS was apparent. Triggers which resulted in worsening symptoms or flares discussed by the groups were all consistent with well-recognised triggers for IBS in the literature and clinical practice. Few participants (6 out of 24) had tried biotic-based therapies (e.g. probiotics, prebiotics) and knew little to nothing about HMOs.
CONCLUSIONS
Individuals with IBS could be made more aware of novel therapy options such as prebiotic HMOs which may improve IBS symptoms.
目的
探讨肠易激综合征（IBS）对生活质量（QoL）指标的影响，特别关注所经历的症状及其对饮食、生活方式和情绪的影响。深入了解IBS发作的触发因素以及使用益生元（特别是人乳寡糖，HMOs）的潜在障碍，将为一项前瞻性人体饮食干预试验的设计提供依据。
方法
在2022年3月至2023年1月期间举行了五次虚拟焦点小组会议。在英国伯克郡及通过社交媒体招募了13名女性和11名男性参加单一的同性焦点小组。对会议记录进行了主题分析。主题使用语义编码树进行组织。
结果
IBS患者的生活质量明显较低。各小组讨论的导致症状加重或发作的触发因素均与文献和临床实践中公认的IBS触发因素一致。很少有参与者（24人中的6人）尝试过基于生物制剂的疗法（如益生菌、益生元），对HMOs几乎一无所知。
结论
可以让IBS患者更多地了解益生元HMOs等新型治疗选择，这些可能会改善IBS症状。
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