Khoshkhui Maryam, Safari Tirtashi Morteza, Movahedi Aliabadi Mehraneh, Rastgoo Sahar, Gharib Masoumeh
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Sabzevar University of Medical Sciences, Sabzevar, Iran.
Arch Dermatol Res. 2025 May 30;317(1):790. doi: 10.1007/s00403-025-04272-1.
Chronic spontaneous urticaria (CSU) characterized by recurrent wheals and/or angioedema, remains a challenging condition. Autoallergic and autoimmune mechanisms (Type I and IIb) have been recognized for CSU pathogenesis. Studies have demonstrated the association between CSU and serum anti-thyroid peroxidase (TPO) antibodies (Abs). However, the potential for increased TPO expression within affected skin tissue of CSU patients is unclear. Patients diagnosed with CSU were recruited from the UCARE center of Mashhad University of Medical Sciences, the case group. Matched healthy individuals who underwent cosmetic surgery served as the control group. Skin biopsies were obtained from active wheal lesions in the CSU patients. Thyroid function tests (TFTs) and serum anti-TPO Ab levels were measured in both groups. Immunohistochemistry (IHC) staining was used to assess skin biopsy samples. A total of 60 participants were enrolled, including 30 CSU patients and 30 healthy controls. Hypothyroidism was significantly more prevalent in the case group compared to controls (p = 0.007). Additionally, the patients exhibited a significantly higher rate of positive serum anti-TPO Ab compared to the healthy individuals (p = 0.001). Notably, IHC staining revealed no TPO expression in the skin samples of either group. This study demonstrated that elevated serum anti-TPO Ab levels in CSU patients may not directly translate to TPO expression within affected skin tissue. While further research with larger cohorts is warranted, our findings contribute to the understanding of the histopathological underpinnings of CSU in relation to TPO, anti-TPO Ab, and potential autoimmune mechanisms.
慢性自发性荨麻疹（CSU）以反复出现风团和/或血管性水肿为特征，仍然是一种具有挑战性的病症。自身过敏和自身免疫机制（I型和IIb型）已被认为与CSU的发病机制有关。研究表明CSU与血清抗甲状腺过氧化物酶（TPO）抗体（Abs）之间存在关联。然而，CSU患者受影响皮肤组织中TPO表达增加的可能性尚不清楚。从马什哈德医科大学UCARE中心招募被诊断为CSU的患者作为病例组。接受整形手术的匹配健康个体作为对照组。从CSU患者的活动性风团皮损处获取皮肤活检样本。测量两组的甲状腺功能测试（TFTs）和血清抗TPO Ab水平。采用免疫组织化学（IHC）染色评估皮肤活检样本。共纳入60名参与者，包括30名CSU患者和30名健康对照。与对照组相比，病例组甲状腺功能减退症的患病率显著更高（p = 0.007）。此外，与健康个体相比，患者血清抗TPO Ab阳性率显著更高（p = 0.001）。值得注意的是，IHC染色显示两组皮肤样本中均无TPO表达。这项研究表明，CSU患者血清抗TPO Ab水平升高可能不会直接转化为受影响皮肤组织中的TPO表达。虽然需要对更大的队列进行进一步研究，但我们的发现有助于理解CSU在TPO、抗TPO Ab和潜在自身免疫机制方面的组织病理学基础。
