ElGhareeb Mohamed Ibrahim, Mokadem Sahar El, Sayed Basma El, Khalifa Naglaa
Dermatology Department.
Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Dermatol Reports. 2019 Dec 20;11(2):8265. doi: 10.4081/dr.2019.8265. eCollection 2019 Sep 19.
Contrary to other inflammatory skin disorders like psoriasis or atopic dermatitis, vitiligo does not present with distinct inflammatory symptoms that can be easily evaluated by clinical examination. Identification of a putative biomarker to inform early and accurate treatment responses could be of considerable value. This study aims to validate levels of serum soluble CD27 (sCD27) and macrophage Migration Inhibitory Factor (MIF) as biomarkers of vitiligo to improve the quality of disease management. This cross-sectional study was conducted on 32 vitiligo patients, stratified into two subgroups of 22 active and 10 stable vitiligo patients; the stable group containing 1 segmental and 9 nonsegmental presentations, and 32 matched healthy individuals as the control group. Of the 32 patients in the study, 21 were female and 11 were male with a median age of 30 years. The measurements of the study parameters of sCD27 and MIF in the serum were carried out through blood sampling and followed up for three months at onemonth intervals for stable vitiligo cases. Mean serum levels of sCD27 and MIF were significantly higher in vitiligo patients than in the control group. A positive correlation was observed in active vitiligo cases between both serum MIF and sCD27 levels and the spreading item of Vitiligo European Task Force (VETF) score as an indicator of disease activity. Serum sCD27 and MIF levels in vitiligo patients were observed to be higher than that of controls with greater correlation found for sCD27 with disease activity.
与银屑病或特应性皮炎等其他炎症性皮肤病不同，白癜风没有明显的炎症症状，难以通过临床检查轻易评估。鉴定一种假定的生物标志物以指导早期和准确的治疗反应可能具有相当大的价值。本研究旨在验证血清可溶性CD27（sCD27）和巨噬细胞迁移抑制因子（MIF）水平作为白癜风的生物标志物，以提高疾病管理质量。本横断面研究对32例白癜风患者进行，分为22例活动期和10例稳定期白癜风患者两个亚组；稳定组包括1例节段型和9例非节段型表现，以及32例匹配的健康个体作为对照组。在研究的32例患者中，21例为女性，11例为男性，中位年龄为30岁。通过采血对血清中sCD27和MIF的研究参数进行测量，并对稳定期白癜风病例每隔1个月随访3个月。白癜风患者血清sCD27和MIF的平均水平显著高于对照组。在活动期白癜风病例中，血清MIF和sCD27水平与白癜风欧洲工作组（VETF）评分的扩展项之间存在正相关，VETF评分作为疾病活动的指标。观察到白癜风患者血清sCD27和MIF水平高于对照组，且发现sCD27与疾病活动的相关性更大。
