Udut V V, Demkin V P, Melnichuk S V, Rudenko T V, Svetlik M V, Akinina M D, Demkin O V, Smaglii L V, Alifirova V M, Grebenuk O V
National Research Tomsk State University, Tomsk, Russia.
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Tomsk, Russia.
Bull Exp Biol Med. 2025 Apr;178(6):697-701. doi: 10.1007/s10517-025-06400-3. Epub 2025 May 30.
A numerical experiment was conducted to determine the spectral sensitivity and selectivity of the cellular components of the utricle and saccule of a laboratory animal (rat) to a periodic electrical stimulation. Equivalent electrical circuit of otolith replacement was used. Its parameters were determined from the anatomical structure and from the measured specific characteristics of cellular elements taking into account the changing ionic conductivity. It was found that the frequency dependence of the impedance and the spectral sensitivity of the cell elements for the utricle and saccule have a resonant nature. The obtained data about the mechanisms of electrical stimulation of hair cells, their spectral sensitivity, and frequency selectivity can serve as the basis for choosing the optimal mode of electrical stimulation in a vestibular implant.
进行了一项数值实验，以确定实验动物（大鼠）椭圆囊和球囊的细胞成分对周期性电刺激的光谱敏感性和选择性。使用了耳石替代的等效电路。其参数是根据解剖结构以及考虑到离子电导率变化的细胞元件的测量特定特性确定的。发现椭圆囊和球囊的细胞元件的阻抗频率依赖性和光谱敏感性具有共振性质。所获得的关于毛细胞电刺激机制、其光谱敏感性和频率选择性的数据可作为选择前庭植入物中最佳电刺激模式的基础。
