Antonov O S, Vlasov Iu A, Litasova E E, Obukhov V N, Pinegin S L
Kardiologiia. 1977 Jan;17(1):80-4.
The results of functional pharmacological tests with nitroglycerine and carbon dioxide gas are presented for patients with congenital heart diseases and pulmonary hypertension, as shown during right heart catheterization. It was established that nitroglycerine, taken sublingually, does not produce any direct effect on the pulmonary artery pressure, and the delayed changes in haemodynamics are a consequence of the altered regimen of pressure in the general circulation. When carbon dioxide gas was administered into the pulmonary artery, it proved to produce a direct effect upon the receptors of the pulmonary arterial bed. However, along with the hypotensive effect, in some cases the carbon dioxide gas increases the pressure in the pulmonary artery due to the embologenic effect of the gas bubbles. Both agents affect the arterial pressure irrespective of the patient's age, the nature of the heart disease, and the degree of pulmonary hypertension.
本文展示了先天性心脏病和肺动脉高压患者在右心导管检查期间使用硝酸甘油和二氧化碳气体进行功能药理学测试的结果。结果表明，舌下含服硝酸甘油对肺动脉压无直接影响，血流动力学的延迟变化是体循环压力变化的结果。当向肺动脉注入二氧化碳气体时，它被证明对肺动脉床的受体有直接作用。然而，除降压作用外，在某些情况下，由于气泡的栓塞作用，二氧化碳气体会增加肺动脉压力。这两种药物对动脉压的影响与患者年龄、心脏病类型和肺动脉高压程度无关。
