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巴西某州十年小儿肾移植回顾性队列研究:临床概况、主要并发症及预后

Retrospective cohort of a decade of pediatric kidney transplant in a Brazilian state: Clinical profile, main complications, and outcomes.

作者信息

Lordelo Marina da Rocha, Nunes Claudia Andrade, Araújo-Pereira Mariana, Barreto-Duarte Beatriz, Andrade Bruno B

机构信息

Programa de Pós-Graduação em Medicina e Saúde Humana, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Bahia, Brazil.

Departamento de Pediatria, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Bahia, Brazil.

出版信息

PLoS One. 2025 May 30;20(5):e0323648. doi: 10.1371/journal.pone.0323648. eCollection 2025.

Abstract

Pediatric kidney transplant is performed globally, although unevenly, with specific challenges in low-income countries with limited resources. We aimed to describe pediatric kidney transplantation in Bahia, a state located in one of the poorest regions in Brazil, and explore possible predictors of survival. This was a single-center retrospective cohort, and we included 101 pediatric kidney transplants performed between 2013 and 2022. There was no predominance of sex; the median age was 12 years old. Congenital anomalies of the kidney and urinary tract were the most common etiology of renal disease. 21 transplants were preemptive. Delayed graft function occurred in just over half of transplants. Patient survival rate was 96%, 96%, 89.1%, and 89.1% respectively at 1-year, 3-years, 5-years, and 10-years post-transplant. The overall graft survival rate was 80.2%, 76.9%, 66.8%, and 45.8% at 1-year, 3-years, 5-years, and 10-years post-transplant. Multivariate analysis of outcome predictors revealed that delayed graft function was a risk factor for graft survival in 5 years (adjusted HR 3.44 (1,18-10,05)). Pediatric kidney transplantation is a regionally feasible treatment, with good outcomes, although slightly inferior to those reported in the literature; efforts on reducing incidence in delayed graft function may improve graft survival.

摘要

全球都在开展小儿肾移植手术,不过分布并不均衡,在资源有限的低收入国家存在特殊挑战。我们旨在描述位于巴西最贫困地区之一的巴伊亚州的小儿肾移植情况,并探究可能的生存预测因素。这是一项单中心回顾性队列研究,我们纳入了2013年至2022年间进行的101例小儿肾移植手术。性别无明显优势;中位年龄为12岁。肾脏和尿路先天性异常是最常见的肾病病因。21例移植为抢先移植。超过半数的移植出现了移植肾功能延迟恢复。移植后1年、3年、5年和10年的患者生存率分别为96%、96%、89.1%和89.1%。移植后1年、3年、5年和10年的总体移植物生存率分别为80.2%、76.9%、66.8%和45.8%。对结局预测因素的多变量分析显示,移植肾功能延迟恢复是5年移植物存活的危险因素(校正风险比3.44(1.18 - 10.05))。小儿肾移植是一种在该地区可行的治疗方法,效果良好,尽管略逊于文献报道;努力降低移植肾功能延迟恢复的发生率可能会提高移植物存活率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7370/12124757/39ab8e0f6cd0/pone.0323648.g001.jpg

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