Health Management and Social Development Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Epidemiology, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Pediatr. 2022 Aug 24;22(1):503. doi: 10.1186/s12887-022-03545-2.
This study is a systematic review and meta-analysis on published studies about the Global Survival Rate of Graft and Patients in the Kidney Transplantation of children.
Studies that investigated the survival rate of kidney transplants published until the 30th of December 2020 were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane. The extracted data were entered into the Excel software and STATA 16.0. The search identified 6007 study references. From the total, we excluded 1348 duplicates, 3688 reference titles and abstracts that were deemed irrelevant, and 846 references that were not original articles (i.e., letter, commentary, review) or did not meet the inclusion criteria. As such, 89 studies involving 12,330 participants were included in this meta-analysis.
In this study 1, 3, 5, 7 and 10-year survival rates of graft were estimated to be 92, 83, 74.40, 67.10, and 63.50%, respectively. Also, 1, 3, 5, 7 and 10-year survival rates of patients were estimated to be 99.60, 97.30, 95.20, 74.60, and 97.90%, respectively.
The findings suggest differences in graft and patient survival among children with kidney transplants. Although differences in ethnic origin, incompatibility with deceased donor kidneys, and types of kidney disease are unavoidable, interventions to improve preventive and living-donor transplantation are particularly needed in minority groups. In addition, more research is needed to establish and address the contribution of medical and sociocultural barriers to preferential treatment of these groups.
本研究是对儿童肾移植中移植物和患者全球存活率的已发表研究进行的系统评价和荟萃分析。
采用系统检索策略，在 Medline、Embase、Scopus、ProQuest、ISI Web of Science 和 Cochrane 数据库中检索截至 2020 年 12 月 30 日发表的研究，调查肾移植存活率。提取的数据输入 Excel 软件和 STATA 16.0。搜索共确定了 6007 篇研究参考文献。从总数中，我们排除了 1348 篇重复文献、3688 篇标题和摘要认为不相关的文献以及 846 篇不是原始文章（即信函、评论、综述）或不符合纳入标准的文献。因此，有 89 项研究共涉及 12330 名参与者纳入了本荟萃分析。
在这项研究中，移植物的 1、3、5、7 和 10 年存活率估计分别为 92%、83%、74.40%、67.10%和 63.50%。此外，患者的 1、3、5、7 和 10 年存活率估计分别为 99.60%、97.30%、95.20%、74.60%和 97.90%。
研究结果表明，儿童肾移植中移植物和患者的存活率存在差异。尽管在民族起源、与已故供体肾脏的不兼容性以及肾脏疾病类型方面存在差异，但需要特别关注少数民族群体，以改善预防和活体供者移植的干预措施。此外，需要进一步研究以确定和解决医疗和社会文化障碍对这些群体的优先待遇的贡献。
