推进蛋白质组学分析以理解疾病生物学并发现生物标志物。

Advancing proteomic analysis for understanding disease biology and biomarker discovery.

作者信息

Cruchaga Carlos

机构信息

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; NeuroGenomics and Informatics Center, Washington University, St. Louis, MO, USA; Hope Center for Neurologic Diseases, Washington University, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO, USA.

出版信息

Cell. 2025 May 29;188(11):2829-2831. doi: 10.1016/j.cell.2025.04.040.

DOI:10.1016/j.cell.2025.04.040

PMID:40446355

Abstract

Advances in proteomics research have enhanced our understanding of disease biology. In a recent issue of Cell, Malmström et al. constructed a comprehensive proteome atlas linking proteins to specific tissues and blood cells to enable tracking of pathological changes and paving the way for broader applications in plasma proteomics across diverse diseases.

摘要

蛋白质组学研究的进展加深了我们对疾病生物学的理解。在最近一期的《细胞》杂志上，马尔姆斯特伦等人构建了一个全面的蛋白质组图谱，将蛋白质与特定组织和血细胞联系起来，以便追踪病理变化，并为血浆蛋白质组学在各种疾病中的更广泛应用铺平道路。