Yao Penglai, Ou Jiale, Zhao Dede, Zhou Shuping, Wang Qi, Feng Yan, Chen Man, Meng Xiangming
School of Chemistry and Chemical Engineering & Institutes of Physical Science and Information Technology, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials & Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, PR China.
School of Chemistry and Chemical Engineering & Institutes of Physical Science and Information Technology, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials & Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, PR China.
J Hazard Mater. 2025 Aug 15;494:138765. doi: 10.1016/j.jhazmat.2025.138765. Epub 2025 May 27.
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have emerged as global concerns due to their environmental persistence and associated toxicity. Therefore, accurate detection of PFOA/PFOS in water samples and biological systems is of great importance. In this study, we have designed and synthesized a novel fluorescent sensor ES based on tetraphenyl derivatives for one-step concurrent detection of PFOA and PFOS. The sensor exhibits a rapid response, high selectivity, high sensitivity, and a large Stokes shift. Both experimental and theoretical calculations indicate that PFOA/PFOS induced aggregation of the sensor ES through electrostatic and hydrophobic interactions, thereby activating its aggregation-induced emission (AIE) effect. The sensor ES can be further utilized for the detection of PFOA/PFOS in real water samples, and a portable smartphone-based analyzer system has been developed for rapid on-site detection. In addition, ES demonstrates low biotoxicity, which enhances its applicability in detecting PFOA/PFOS in living cells, zebrafish, and mice. This suggests the potential of ES for biological applications in the real-time monitoring PFOA/PFOS.
全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）因其在环境中的持久性和相关毒性而成为全球关注的问题。因此，准确检测水样和生物系统中的PFOA/PFOS至关重要。在本研究中，我们设计并合成了一种基于四苯基衍生物的新型荧光传感器ES，用于一步同时检测PFOA和PFOS。该传感器具有快速响应、高选择性、高灵敏度和大斯托克斯位移。实验和理论计算均表明，PFOA/PFOS通过静电和疏水相互作用诱导传感器ES聚集，从而激活其聚集诱导发光（AIE）效应。传感器ES可进一步用于实际水样中PFOA/PFOS的检测，并且已经开发了一种基于便携式智能手机的分析仪系统用于快速现场检测。此外，ES表现出低生物毒性，这增强了其在检测活细胞、斑马鱼和小鼠中PFOA/PFOS的适用性。这表明ES在实时监测PFOA/PFOS的生物应用方面具有潜力。
