St-Laurent Audrey, Belan Matea, Jean-Denis Farrah, Langlois Marie-France, Pesant Marie-Hélène, Carranza-Mamane Belina, Duval Karine, Morisset Anne-Sophie, Baillargeon Jean-Patrice
Research Center of Centre Hospitalier Universitaire (CHU) de Québec - Université Laval, Québec, QC, Canada; Nutrition School of Université Laval, Québec, QC, Canada.
Department of Medicine, Division of Endocrinology, Université de Sherbrooke, Sherbrooke, QC, Canada.
Clin Nutr ESPEN. 2025 Aug;68:457-464. doi: 10.1016/j.clnesp.2025.05.036. Epub 2025 May 28.
BACKGROUND & AIMS: There are few effective interdisciplinary lifestyle programs aiming to support women with obesity who are seeking fertility treatments. This study aims to determine whether the Obesity-Fertility lifestyle program leads to healthier lifestyle behaviours in women with obesity and subfertility compared to controls.
This is a secondary analysis of an open-label randomized controlled trial whose primary outcome was live birth rate. Women with obesity and subfertility were randomized to the lifestyle (LSG = 65) or control (CG = 65) groups. The LSG participated in individual and group sessions with a dietitian and a kinesiologist, while the CG received the usual care of the fertility clinic. Data on food consumption, physical activity, sedentary time, and smoking and alcohol use were collected before and 6 months after the intervention. Functional capacity was evaluated with a 6-min walk test (6MWT). Changes in lifestyle after 6 months were compared between groups with p-values corrected for the outcome baseline data.
From January 2012 to September 2016, 130 women were randomized, 85 of whom had data available at 6 ± 1 months (LSG = 42 and CG = 43). Groups had similar sociodemographic characteristics and lifestyle behaviours at baseline, except for lower prevalence of smoking in LSG (9.5 %) vs CG (34.9 %) (p = 0.005). After 6 months of follow-up, and compared to the CG, women in the LSG significantly improved their intake of whole fruits (+1.1 ± 1.2 vs +0.4 ± 0.8/day, p = 0.001), whole grain products (+1.0 ± 1.3 vs +0.04 ± 1.2/day, p < 0.001), dairy products (+0.4[0; 0.9] vs -0.1[-0.7; 0.3]/day, p < 0.001); breakfast frequency (+1.4 ± 2.6 vs +0.5 ± 1.8/week, p < 0.001); proportion of active women (>3 kcal/kg/day: +14.2 % vs +2.3 %, p = 0.003); and time spent in sedentary behaviour (-6.7 vs -0.1 h/week, p < 0.005). Distance covered during the 6MWT tended to increase more in LSG vs CG (+28.8 ± 42.1 vs +5.5 ± 42.6 m, p = 0.06). No significant difference was found between groups for sleep duration, alcohol consumption and smoking use.
After 6 months, the Obesity-Fertility program significantly improved diet quality, physical activity level and sedentary behaviour in women with obesity and subfertility. Such programs can therefore support these women to adopt healthier lifestyle behaviours.
NCT01483612.
旨在为寻求生育治疗的肥胖女性提供支持的有效跨学科生活方式项目较少。本研究旨在确定与对照组相比，肥胖 - 生育生活方式项目是否能使肥胖和生育力低下的女性养成更健康的生活方式行为。
这是一项对开放标签随机对照试验的二次分析，其主要结局是活产率。肥胖和生育力低下的女性被随机分为生活方式干预组（LSG = 65）或对照组（CG = 65）。LSG组的女性与营养师和运动生理学家一起参加了个人和小组课程，而CG组接受生育诊所的常规护理。在干预前和干预后6个月收集了关于食物消费、身体活动、久坐时间以及吸烟和饮酒情况的数据。通过6分钟步行试验（6MWT）评估功能能力。使用针对结局基线数据校正的p值比较两组在6个月后生活方式的变化。
从2012年1月至2016年9月，130名女性被随机分组，其中85名在6±1个月时有可用数据（LSG = 42，CG = 43）。两组在基线时具有相似的社会人口学特征和生活方式行为，但LSG组吸烟率（9.5%）低于CG组（34.9%）（p = 0.005）。经过6个月的随访，与CG组相比，LSG组的女性显著增加了全水果摄入量（+1.1±1.2对+0.4±0.8/天，p = 0.001）、全谷物产品摄入量（+1.0±1.3对+0.04±1.2/天，p < 0.001）、乳制品摄入量（+0.4[0; 0.9]对 -0.1[-0.7; 0.3]/天，p < 0.001）；早餐频率（+1.4±2.6对+0.5±1.8/周，p < 0.001）；活跃女性比例（>3千卡/千克/天：+14.2%对+2.3%，p = 0.003）；以及久坐行为时间（-6.7对 -0.1小时/周，p < 0.005）。与CG组相比，LSG组在6MWT期间行走的距离增加趋势更明显（+28.8±42.1对+5.5±42.6米，p = 0.06）。两组在睡眠时间、饮酒和吸烟方面未发现显著差异。
6个月后，肥胖 - 生育项目显著改善了肥胖和生育力低下女性的饮食质量、身体活动水平和久坐行为。因此，此类项目可以支持这些女性养成更健康的生活方式行为。
NCT01483612
