Sarmiento Varón Lindybeth, Alvarez Hermy, Huirimilla Casanova Leyla Carolina, Díaz Mora Maria Paz, Muñoz Cuevas Luis Alfredo, Gonzalez-Puelma Jorge, Espinoza Karena, Amarales Lidia, Lühr Henriquez Jonathan, Retamal-Matus Felipe, Uribe-Paredes Roberto, Núñez-Espinosa Cristian Andrés, Estrada-Goic Claudia, Bachelet Vivienne C, López Nitsche Mercedes N, Navarrete Marcelo A
Centro Asistencial Docente e Investigación, Universidad de Magallanes, Punta Arenas, Chile.
Escuela de Medicina, Universidad de Magallanes, Punta Arenas, Chile.
BMJ Open. 2025 May 30;15(5):e093844. doi: 10.1136/bmjopen-2024-093844.
The COVID-19 pandemic, driven by the SARS-CoV-2 virus, has had a significant global impact, with over 775 million cases reported and more than 7 million deaths as of July 2024. In Chile, approximately 5.4 million people have been infected, with a substantial proportion experiencing persistent symptoms known as post-COVID-19 syndrome. This study aims to estimate the prevalence of post-COVID-19 syndrome in Punta Arenas, Chile, and to explore the associated symptoms, mainly focusing on psychological, physical and molecular impacts on the affected population.
This cross-sectional study will use stratified random sampling to select a representative sample of 282 adults from Punta Arenas. Participants eligible for the study are those who had tested positive for SARS-CoV-2 by reverse transcription-quantitative PCR between July 2022 and July 2023. Data collection will include comprehensive clinical assessments, psychological evaluations and laboratory analyses of inflammatory biomarkers. Standardised instruments will be used to ensure consistency and reliability in measuring persistent symptoms. Statistical analyses will include descriptive statistics, regression models and subgroup analyses to identify risk factors and the prevalence of post-COVID-19 syndrome.
The Human Research Ethics Committee of the Clinical Hospital of the University of Chile approved the study protocol (Memorandum No 007/2023). We will present the results in peer-reviewed publications and national and international professional and academic meetings.
NCT05855382.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引发的新冠疫情对全球产生了重大影响，截至2024年7月，报告的病例超过7.75亿例，死亡人数超过700万。在智利，约有540万人感染，其中很大一部分人出现了被称为新冠后综合征的持续症状。本研究旨在估计智利蓬塔阿雷纳斯市新冠后综合征的患病率，并探究相关症状，主要关注对受影响人群的心理、身体和分子影响。
这项横断面研究将采用分层随机抽样方法从蓬塔阿雷纳斯市选取282名成年人作为代表性样本。符合研究条件的参与者是那些在2022年7月至2023年7月期间通过逆转录定量PCR检测SARS-CoV-2呈阳性的人。数据收集将包括全面的临床评估、心理评估以及炎症生物标志物的实验室分析。将使用标准化工具以确保在测量持续症状时的一致性和可靠性。统计分析将包括描述性统计、回归模型和亚组分析，以确定新冠后综合征的危险因素和患病率。
智利大学临床医院的人类研究伦理委员会批准了该研究方案（第007/2023号备忘录）。我们将在同行评审的出版物以及国内和国际专业学术会议上展示研究结果。
NCT05855382。
