Correlation between postprandial hypotension and post-induction hypotension in the elderly: a protocol for a prospective cohort study.

INTRODUCTION

Post-induction hypotension (PIH) is particularly common in elderly patients undergoing general anaesthesia and is associated with severe postoperative complications. Autonomic nervous system (ANS) dysfunction is a potential risk factor for significant haemodynamic fluctuations during general anaesthesia in elderly patients. Tools to identify ANS are currently lacking in perioperative clinical practice. Postprandial hypotension (PPH) is closely linked to ANS dysfunction and is also common among elderly individuals. Therefore, this study aims to explore the relationship between PPH and PIH in elderly patients undergoing non-cardiac surgery. By examining this correlation, we hope to better understand the factors contributing to PIH and explore the potential role of PPH in predicting PIH.

METHODS AND ANALYSIS

This is a prospective observational cohort study. 120 elderly Chinese patients aged ≥65 years and scheduled to undergo non-cardiac surgery under general anaesthesia at Peking Union Medical College Hospital (PUMCH) will be included. PPH assessments will include baseline pre-prandial records and blood pressure measurements immediately after meal completion, followed by every 5 min for 120 min. To evaluate PIH, blood pressure will be monitored from the patients' entry into the operating room until 20 min after anaesthesia induction or the initiation of surgery. PIH is defined as systolic blood pressure of <90 mmHg or main arterial pressure <65 mmHg or a decrease of more than 30% from baseline within 20 min after general anaesthesia induction or before surgical incision. Baseline assessment will include regular preoperative assessment, symptoms and medical history related to baroreflex dysfunction, and preoperative volume status will be assessed by passive leg raising test. Follow-up will be conducted at 1, 3, 7 and 30 days and 6 months postoperatively. The primary outcome is PIH. Secondary outcomes include early intraoperative hypotension, postoperative complications graded by Clavien-Dindo classification, 30-day postoperative mortality and 12-item WHO Disability Assessment Schedule 2.0 (12-item WHODAS 2.0) score 6 months postoperatively.

ETHICS AND DISSEMINATION

This study has been registered in the ClinicalTrials.gov system of the National Institutes of Health (registration number NCT05575661). The Ethics Committee of PUMCH has also granted ethical approval (approval number I-22PJ008). The study results will be disseminated through publication in peer-reviewed journals focused on anaesthesiology and geriatric medicine, as well as presentations at relevant scientific conferences.

TRIAL REGISTRATION NUMBER

NCT05575661.