壳聚糖减轻二氧化钛纳米颗粒诱导的肝脏和肾脏毒性。
Chitosan attenuates titanium dioxide nanoparticles induced hepatic and renal toxicities.
作者信息
Halawa Amal Abdelmonem, Elshopakey Gehad, El-Adl Mohamed, Lashen Samah, Shalaby Nancy, Rezk Shaymaa, Elmetwally Omar, Eldomany Ehab, Farghali Ahmed, Elmetwally Mohamed
机构信息
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
出版信息
Sci Rep. 2025 May 30;15(1):18983. doi: 10.1038/s41598-025-01736-2.
Titanium dioxide nanoparticles (TiO NPs) are extensively incorporated in numerous industrial products. Adult male Albino rats received oral TiO NPs at a dose of 150 mg/kg body weight for 14 days exhibited both hepatic and renal toxicities manifested by disruption in serum hepatic and renal biomarkers, imbalance in oxidative-antioxidant system, up-regulation of mRNA expression of genes encode inflammation (IL-1β, TNF-α) and apoptosis (Caspase-3, BAX) with down-regulation of PCNA immune-staining density and histological modifications in hepatic and renal architecture. Carboxymethyl chitosan (5 mg/kg BW) significantly improved the harmful effects of nano-titanium particles highlighting its relevance in reducing TiO NPs - induced hepatic and renal dysfunction.
二氧化钛纳米颗粒（TiO NPs）被广泛应用于众多工业产品中。成年雄性白化大鼠以150毫克/千克体重的剂量口服TiO NPs，持续14天，结果显示出肝脏和肾脏毒性，表现为血清肝脏和肾脏生物标志物紊乱、氧化-抗氧化系统失衡、编码炎症（IL-1β、TNF-α）和凋亡（Caspase-3、BAX）的基因mRNA表达上调，同时增殖细胞核抗原免疫染色密度下调，以及肝脏和肾脏结构的组织学改变。羧甲基壳聚糖（5毫克/千克体重）显著改善了纳米钛颗粒的有害影响，突出了其在减轻TiO NPs诱导的肝脏和肾脏功能障碍方面的作用。
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