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阻塞性睡眠呼吸暂停的临床特征及治疗偏好

Clinical characteristics and treatment preferences of obstructive sleep apnea.

作者信息

Kraiwattanapong Jarungjit, Rattanaarun Kotchakarn, Cunteerasup Amonwan, Papassornsiri Tipyada, Balankura Tonkla, Pavarajarn Supawat

机构信息

Department of Otolaryngology Head and Neck surgery, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, 222 Tiwanon Road, Pakkret, Nonthaburi, 11120, Thailand.

Division of pulmonary medicine and pulmonary critical care, Department of Medicine Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, 222 Tiwanon Road, Pakkret, Nonthaburi, 11120, Thailand.

出版信息

Sci Rep. 2025 May 30;15(1):18976. doi: 10.1038/s41598-025-03816-9.

Abstract

This study examines the clinical characteristics, comorbidities, and treatment preferences of patients with obstructive sleep apnea (OSA) to guide personalized treatment strategies. A cross-sectional analysis of 377 patients who underwent polysomnography was conducted, categorizing participants into three groups based on their chief complaints: sleepiness, disturbed sleep, and asymptomatic with comorbidities. Key factors such as body mass index (BMI), comorbid conditions, oxygen saturation levels, and sleep fragmentation influenced treatment choices. Continuous positive airway pressure (CPAP) was the most preferred treatment, particularly among patients with high BMI, cardiovascular comorbidities, and severe OSA (Apnea Hypopnea Index [AHI] > 30 events per hour). Patients with excessive daytime sleepiness favored CPAP due to lower oxygen saturation levels, while those with disturbed sleep were influenced by high sleep fragmentation. Individuals with metabolic syndrome showed mixed treatment preferences, with a small proportion opting for bariatric or upper airway surgery. These findings highlight the importance of tailoring OSA treatments based on patient phenotypes to optimize outcomes and improve quality of life.

摘要

本研究探讨阻塞性睡眠呼吸暂停(OSA)患者的临床特征、合并症及治疗偏好,以指导个性化治疗策略。对377例接受多导睡眠图检查的患者进行横断面分析,根据主要诉求将参与者分为三组:嗜睡、睡眠障碍以及有合并症但无症状。体重指数(BMI)、合并症情况、血氧饱和度水平和睡眠片段化等关键因素影响治疗选择。持续气道正压通气(CPAP)是最常用的治疗方法,尤其是在BMI高、有心血管合并症和重度OSA(呼吸暂停低通气指数[AHI]>每小时30次事件)的患者中。白天过度嗜睡的患者因血氧饱和度水平较低而倾向于使用CPAP,而睡眠障碍患者则受高睡眠片段化影响。代谢综合征患者的治疗偏好不一,一小部分人选择减肥手术或上气道手术。这些发现凸显了根据患者表型定制OSA治疗以优化治疗效果和改善生活质量的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/baeb/12125185/e0533288d703/41598_2025_3816_Fig1_HTML.jpg

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