Innes P B
J Craniofac Genet Dev Biol. 1985;5(3):287-97.
The effect of methylprednisolone on the structure of the mesenchymal component of the palatal shelves of fetal mice was studied at the time of shelf reorientation. Pregnant mice received intraperitoneal injections of 8 mg of prednisolone on days 11.5, 12.5, and 13.5 of pregnancy. The mice were killed on day 14.5, and the specimens were either stained with periodic acid-Schiff (PAS) reagent for examination in the light microscope or processed for examination in the electron microscope. It was found that prednisolone treatment resulted in a reduction in the amount of tannic-acid-staining material in the extracellular spaces. It also resulted in a reduction in the collagen within the shelf. The development of skeletal and smooth muscle cells, neurons, and satellite cells was also delayed and the occurrence within the shelves of cells with a high glycogen content was reduced.
在腭突重新定位时，研究了甲基泼尼松龙对胎鼠腭突间充质成分结构的影响。怀孕小鼠在妊娠第11.5、12.5和13.5天接受8毫克泼尼松龙的腹腔注射。在第14.5天处死小鼠，标本用高碘酸-希夫（PAS）试剂染色，用于光学显微镜检查，或进行处理用于电子显微镜检查。发现泼尼松龙治疗导致细胞外间隙中鞣酸染色物质的量减少。它还导致腭突内的胶原蛋白减少。骨骼肌细胞、平滑肌细胞、神经元和卫星细胞的发育也延迟，且腭突内糖原含量高的细胞出现减少。
