Merghany Rana M, Saleh Rofida A, Hamed Ahmed A, El-Dessouki Ahmed M, El-Shiekh Riham A, Zaki Eman S, Mahfoz Amal M
Department of Pharmacognosy, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El-Buhouth Street, Giza, 12622, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Inflammopharmacology. 2025 May 30. doi: 10.1007/s10787-025-01790-2.
Approximately 50% of patients with diabetes mellitus (DM) are known to have significant side effects, including retinopathy, cardiomyopathy, peripheral neuropathy, and nephropathy. Most of these complications are caused by inadequate glycemic control or incorrect pathology management. In any event, diabetic peripheral neuropathy (DPN) appears to be the most common and painful consequence that many DM patients experience. As a result, this review aimed to gather the wide range of treatments used to manage DPN, beginning with the most traditional therapy and progressing to alternative approaches. Medicinal plants and their bioactive compounds have been widely used as natural medicines for various diseases, with little known adverse effects. This review emphasizes the role of medicinal plants and their naturally occurring bioactive components in combating this condition.
已知约50%的糖尿病（DM）患者有严重的副作用，包括视网膜病变、心肌病、周围神经病变和肾病。这些并发症大多是由血糖控制不佳或病理管理不当引起的。无论如何，糖尿病周围神经病变（DPN）似乎是许多糖尿病患者经历的最常见且痛苦的后果。因此，本综述旨在收集用于治疗DPN的广泛治疗方法，从最传统的疗法开始，逐步介绍替代方法。药用植物及其生物活性化合物已被广泛用作治疗各种疾病的天然药物，且几乎没有已知的不良反应。本综述强调了药用植物及其天然存在的生物活性成分在对抗这种疾病中的作用。
