Barre P S, Thompson G H, Morrison S C
J Pediatr Orthop. 1985 Sep-Oct;5(5):584-8. doi: 10.1097/01241398-198509000-00016.
Late skeletal deformities following meningococcemia associated with disseminated intravascular coagulation are rare. Two basic lesions have been described: epiphyseal avascular necrosis and epiphyseal-metaphyseal defects. These occur primarily in the lower extremities and result in angular deformity and leg length inequality. We recently encountered these lesions in a child 3 years following sepsis. The etiology appears to be acute vascular thrombosis of epiphyseal and metaphyseal vessels mediated through the generalized Shwartzman reaction. An increased incidence of these deformities may be anticipated as more children survive fulminant meningococcemia.
与弥散性血管内凝血相关的脑膜炎球菌血症后出现的晚期骨骼畸形较为罕见。已描述了两种基本病变：骨骺缺血性坏死和骨骺-干骺端缺损。这些病变主要发生在下肢，导致成角畸形和腿长不等。我们最近在一名儿童败血症3年后遇到了这些病变。病因似乎是通过全身性施瓦茨曼反应介导的骨骺和干骺端血管急性血栓形成。随着更多儿童在暴发性脑膜炎球菌血症中存活下来，预计这些畸形的发生率会增加。
