Qi Yana, Sun Dongmei, Zhai Xiaoyang, Chen Feihu, Niu Jiling, Zhu Hui
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, Shandong Province, 250117, China.
J Transl Med. 2025 May 30;23(1):602. doi: 10.1186/s12967-025-06556-6.
Metastasis plays a significant role in the high mortality rates associated with cancer and is usually the endpoint of a series of sequential and dynamic events. A crucial step in metastasis development and progression is the formation of a premetastatic niche (PMN), which provides a conducive microenvironment for the settlement and colonization of disseminated tumor cells at distant metastatic sites. Extensive research has demonstrated the significance of macrophage populations within primary tumors in promoting metastatic progression. Nevertheless, the contribution of macrophages at secondary sites to the regulation of PMN formation is frequently overlooked. This review systematically explores the role of macrophages in priming the PMN to facilitate cancer metastasis. Additionally, we provide a compendium of existing strategies to target macrophages in cancer therapy.
转移在与癌症相关的高死亡率中起着重要作用，通常是一系列连续动态事件的终点。转移发展和进展的关键步骤是形成前转移生态位（PMN），它为播散的肿瘤细胞在远处转移部位的定居和定植提供了有利的微环境。广泛的研究表明，原发性肿瘤内的巨噬细胞群体在促进转移进展方面具有重要意义。然而，继发性部位的巨噬细胞对PMN形成调节的贡献常常被忽视。本综述系统地探讨了巨噬细胞在启动PMN以促进癌症转移中的作用。此外，我们提供了一份在癌症治疗中靶向巨噬细胞的现有策略汇编。
