Lazaro-Martinez Jose Luis, Armstrong David G, Chadwick Paul, Gledhill Andrea, Janssen Sandra, Malone Matthew
Universidad Complutense de Madrid, Madrid, Spain.
Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Int Wound J. 2025 Jun;22(6):e70700. doi: 10.1111/iwj.70700.
Diabetes related foot ulcers (DFUs) are complex and costly to manage, with the prevalence of non-healing wounds steadily increasing across the globe. Non-healing wounds can occur when clinicians fail to undertake an appropriate assessment, fail to recognise the importance of systemic or local complications, or provide the optimal treatment. The aetiological causes behind non-healing wounds are multifactorial; however, the purpose of this article is to focus on the role of oxygen in non-healing wounds and to introduce readers to advances in the delivery of topical oxygen therapy (TOT) via a haemoglobin spray. Importantly, this article incorporates a clinical decision support tool (CDST) to help clinicians identify the most appropriate individuals for whom topical haemoglobin may be most beneficial and the most appropriate time for introducing the intervention to improve wound healing outcomes.
糖尿病相关足部溃疡（DFUs）的治疗复杂且成本高昂，全球范围内不愈合伤口的患病率正在稳步上升。当临床医生未能进行适当评估、未认识到全身或局部并发症的重要性或未提供最佳治疗时，就会出现不愈合伤口。不愈合伤口背后的病因是多因素的；然而，本文的目的是关注氧气在不愈合伤口中的作用，并向读者介绍通过血红蛋白喷雾进行局部氧疗（TOT）的进展。重要的是，本文纳入了一种临床决策支持工具（CDST），以帮助临床医生确定最适合接受局部血红蛋白治疗且可能最有益的个体，以及引入该干预措施以改善伤口愈合结果的最合适时间。
