Metcalfe W K
J Comp Neurol. 1985 Aug 8;238(2):218-24. doi: 10.1002/cne.902380208.
The development of neuromasts and sensory neurons of the posterior lateral line was studied in zebrafish (Brachydanio rerio) in order to determine the relationship between growing axons of sensory neurons and the migratory cellular primordium of midbody line neuromasts. Scanning electron microscopy revealed that a primary system of six neuromasts develops during the second day after fertilization and evidence is presented that these arise from cells of a migratory primordium. The primordium is first detected in the postauditory region immediately adjacent to the developing sensory ganglion. Growth cones of posterior lateral line sensory neurons are found within the premigratory primordium when it is adjacent to the ganglion. At later times growth cones of these sensory neurons are found within the primordium as it migrates caudally along the midbody line. These results demonstrate that although the growth cones of the sensory neurons grow over a considerable distance to their final destination, they are never very far from their target cells (or target cell precursors), which migrate with them and may even lead them.
为了确定感觉神经元生长轴突与中体线神经丘迁移细胞原基之间的关系，研究了斑马鱼（短担尼鱼）后侧线神经丘和感觉神经元的发育。扫描电子显微镜显示，受精后第二天会发育出由六个神经丘组成的初级系统，并且有证据表明这些神经丘起源于迁移原基的细胞。原基首先在紧邻发育中的感觉神经节的耳后区域被检测到。当迁移前原基与神经节相邻时，后侧线感觉神经元的生长锥出现在其中。之后，随着原基沿中体线向尾侧迁移，这些感觉神经元的生长锥会出现在原基内。这些结果表明，尽管感觉神经元的生长锥要生长相当长的距离才能到达其最终目的地，但它们与目标细胞（或目标细胞前体）的距离从未很远，目标细胞会与它们一起迁移，甚至可能引导它们。
