Membrane transporters in Plants: Key players in abiotic and biotic stress tolerance and nutritional transport.

Various abiotic and biotic stressors, including water extremes, temperature fluctuations, salinity, and heavy metals, pathogens and diseases significantly reduce global crop yields. Rapid plant responses are essential for adapting and minimizing metabolic losses. In this context, plant transporters (PTs) are essential for modulating stress responses by enabling the passage of diverse molecules and ions through the plasma membrane. Plant transporters play a pivotal role in regulating water and facilitating nutrient uptake, maintaining cellular equilibrium including osmotic regulation, detoxification, biofortification and orchestrating source-to-sink dynamics across different environmental stages in plants. In this review, we delved into recent discoveries concerning diverse transporter families such as ABC, MATE, NRAMP, SWEET, Symporters, STP, KUP, COPT/Ctr, NPF, NRT, PHT, YSL, ZIP and STP. Understanding the functions of these transporters is paramount for elucidating stress tolerance mechanisms and enhancing crop resilience through breeding and gene editing. These specialized plant membrane transporters play a crucial role in securing sustainable economic yields and maintaining high-quality produce, particularly in challenging growth conditions. We explored their contributions to plant robust growth via their crucial role in NPK and secondary metabolite transport. Through an integrated analysis of transporter dynamics during stress, we unveiled the nexus between nutrient management and stress resilience. We also clustered promising techniques that has been achieved to identify PTs such as function-driven screens, phenotype-driven screens and in silico-based approaches and provide a comprehensive overview of these transporters, offering valuable insights for the research community. This review also discusses future prospects for the use of bioinformatic computational tools in constructing signaling networks to improve our understanding of the behavior of transporters under abiotic and biotic stress. In this review, we highlight examples with case studies that illustrated how new technology and computational tools has been utilized in advanced identification and characterization of PTs functions. By strategically manipulating these transporters, we can pave the way for the development of "Plants for the Future."