Li Jialu, Wang Xueyan, Zhao Chun, Wang Huiqi, Lv Lili, Li Zhanfeng, Wang Zonghua
College of Chemistry and Chemical Engineering, Instrumental Analysis Center, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Qingdao 266071, China.
College of Mechanical and Automotive Engineering, Qingdao Hengxing University of Science and Technology, Qingdao 266100, China.
Colloids Surf B Biointerfaces. 2025 Oct;254:114822. doi: 10.1016/j.colsurfb.2025.114822. Epub 2025 May 26.
As a promising anticancer modality, sonodynamic therapy (SDT) is becoming popular with the cooperative services of covalent organic frameworks (COFs). In this review, a comprehensive observation about the COFs-mediated SDT is preached by focusing on the fast-track advances in the cancer treatments. Here, the review not only systematically shows the theranostic applications of COFs-based nanodrugs, but also deeply describes the COFs-mediated SDT according to the Type-I and Type-II activation mechanisms. More importantly, the review hierarchically narrates many successes in the COFs-coordinated multimodal SDT/X platforms, highlighting their competitive superiority and improvements in the anticancer applications. In addition, the review also proposes some possible challenges of COFs-mediated SDT strategies. Accordingly, the development of COFs and SDT in the anticancer platform will promote the technological innovation of nanodrugs and facilitate the close exchange of cancer-related events.
作为一种有前景的抗癌方式，声动力疗法（SDT）在共价有机框架（COF）的协同作用下正变得越来越受欢迎。在本综述中，通过关注癌症治疗的快速进展，对COF介导的SDT进行了全面观察。在此，该综述不仅系统地展示了基于COF的纳米药物的诊疗应用，还根据I型和II型激活机制深入描述了COF介导的SDT。更重要的是，该综述分层叙述了COF协同多模态SDT/X平台的诸多成功案例，突出了它们在抗癌应用中的竞争优势和改进。此外，该综述还提出了COF介导的SDT策略的一些可能挑战。因此，抗癌平台中COF和SDT的发展将促进纳米药物的技术创新，并推动癌症相关事件的密切交流。
