Global dengue epidemic worsens with record 14 million cases and 9000 deaths reported in 2024.

Dengue, caused by the dengue virus (DENV), is the fastest-growing mosquito-borne disease worldwide. We utilised monthly data on dengue cases and deaths reported through the World Health Organisation's (WHO) global surveillance system for the period of 1 January to 31 December 2024. We then performed a generalised linear regression model to understand country-level determinants of dengue-related mortality. In 2024, 14.1 million dengue cases were reported globally, surpassing the historic milestone of 7 million observed in 2023. This figure represents a twofold increase compared to 2023 and a 12-fold rise compared to 2014 (n=1,206,644). In 2024, 9,508 dengue-related deaths were recorded, resulting in a global case-fatality rate of 0.07%. In the regression analysis, countries in the Southern hemisphere (incidence rate ratio [IRR]: 5.95, 95% CI: 4.19-8.46), aged population (IRR 1.04, CI: 1.01-1.07), and mean annual temperature (IRR 1.21, CI: 1.16-1.26) were significantly associated with higher dengue-related mortality per million population. The ongoing dengue outbreak underscores the urgent need for global investment in DENV research, vaccine development, vector control, and therapeutic strategies. We urge the inclusion of DENV in the WHO's Research and Development Priority Disease list to address this growing global health threat.