中国一家三级医院的医护人员中，中国内脏脂肪指数与动脉僵硬度之间的关联。

Association between Chinese visceral adiposity index and arterial stiffness among hospital workers in a Chinese tertiary hospital.

作者信息

Wang Guoyu, Gao Peng, Zhang Qingqing, Xu Hong, Zheng Jing, Jiang Suyun, Sun Si, Cao Jingyuan, Zhu Li

机构信息

Department of Pan-Vascular Management Center, Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, 366 Taihu Road, Hailing District, Taizhou, Jiangsu, 225300, P. R. China.

Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, P. R. China.

出版信息

Diabetol Metab Syndr. 2025 May 31;17(1):184. doi: 10.1186/s13098-025-01746-0.

DOI:10.1186/s13098-025-01746-0

PMID:40450329

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12125740/

Abstract

BACKGROUND

Chinese visceral adiposity index (CVAI) has emerged as a reliable marker of visceral adiposity dysfunction. However, its relationship with arterial stiffness has yet to be comprehensively evaluated. This study investigated the association between CVAI and arterial stiffness in a cohort of hospital workers from a tertiary hospital.

METHODS

A cohort of hospital workers aged more than 35 years old, anticipating in physical examinations from September to October 2024, were enrolled in this study. Arterial stiffness was measured by brachial-ankle pulse wave velocity (baPWV). Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured using the umbilical cord level double bioelectrical impedance analyzer. Correlation analysis, univariate and multivariate regression analysis, as well as receiver operating characteristic (ROC) curve analysis were used.

RESULTS

Our results demonstrated a positive non-linear correlation between CVAI and VFA (p for non-linear: <0.001). CVAI was significantly associated with increased arterial stiffness (odds ratio (OR): 1.033, 95% confidence interval (CI): 1.020-1.046, p <0.001), after adjusting for other confounders. The restricted cubic spline (RCS) analysis indicated a non-linear correlation between the CVAI and arterial stiffness (p for overall: <0.001, p for non-linear: 0.045). The cut-off value of the CVAI for arterial stiffness was 66.11 (sensitivity, 0.711; specificity, 0.620).

CONCLUSIONS

CVAI is an independent predictor of arterial stiffness, suggesting its potential as a clinical tool for identifying individuals at risk of arterial stiffness.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

中国内脏脂肪指数（CVAI）已成为内脏脂肪功能障碍的可靠标志物。然而，其与动脉僵硬度的关系尚未得到全面评估。本研究调查了一家三级医院的医院工作人员队列中CVAI与动脉僵硬度之间的关联。

方法

本研究纳入了一组年龄超过35岁、预计在2024年9月至10月进行体检的医院工作人员。采用臂踝脉搏波速度（baPWV）测量动脉僵硬度。使用脐水平双生物电阻抗分析仪测量内脏脂肪面积（VFA）和皮下脂肪面积（SFA）。采用相关性分析、单因素和多因素回归分析以及受试者工作特征（ROC）曲线分析。

结果

我们的结果表明CVAI与VFA之间存在正非线性相关性（非线性p值：<0.001）。在调整其他混杂因素后，CVAI与动脉僵硬度增加显著相关（优势比（OR）：1.033，95%置信区间（CI）：1.020 - 1.046，p <0.001）。受限立方样条（RCS）分析表明CVAI与动脉僵硬度之间存在非线性相关性（总体p值：<0.001，非线性p值：0.045）。动脉僵硬度的CVAI截断值为66.11（敏感性，0.711；特异性，0.620）。