Singh A K, Rivera R, Cooper G N, Karlson K E
J Am Coll Cardiol. 1985 Nov;6(5):1121-5. doi: 10.1016/s0735-1097(85)80318-1.
Within 30 days of acute myocardial infarction, 108 consecutive patients underwent urgent surgical myocardial revascularization for postinfarction angina between July 1976 and March 1983. There were 84 men and 24 women whose mean age was 59.6 +/- 9.5 years (range 34 to 80). Group I (15 patients, 14%) underwent surgery within 48 hours, Group II (47 patients, 43%) between 3 and 7 days and Group III (46 patients, 43%) within 30 days. Fifty-nine patients (55%) had transmural infarction. The ejection fraction was less than 40% in 21 patients (19%). Left ventricular end-diastolic pressure was 20 mm Hg or greater in 42 patients (39%). The incidence of single, double, triple vessel and 70% or greater left main coronary artery stenosis was 4, 20, 59 and 17%, respectively. There were two deaths (1.8%) within 30 days of operation. The incidence of intraaortic balloon pumping was higher in patients operated on earlier after myocardial infarction (53% of Group I versus 22% of Group III). Statistically, there were no differences in the use of inotropic agents or the occurrence of arrhythmias or postoperative myocardial infarction in the three groups. Late follow-up (mean 35 months, range 18 to 98) is complete for all patients (100%). There were four late myocardial infarctions and eight deaths. Actuarial survival was 87% at 5 years. Seventy-three percent of the 108 patients were free of angina and the condition of 14% improved. These results indicate that myocardial revascularization in the first 30 days after myocardial infarction can be accomplished with morbidity and mortality rates similar to those of an elective operation for chronic angina refractory to medical management.
1976年7月至1983年3月期间,108例急性心肌梗死后30天内的连续患者因梗死后心绞痛接受了紧急外科心肌血运重建术。其中男性84例,女性24例,平均年龄59.6±9.5岁(范围34至80岁)。第一组(15例患者,14%)在48小时内接受手术,第二组(47例患者,43%)在3至7天内接受手术,第三组(46例患者,43%)在30天内接受手术。59例患者(55%)发生透壁梗死。21例患者(19%)射血分数低于40%。42例患者(39%)左心室舒张末期压力为20mmHg或更高。单支、双支、三支血管病变以及左主冠状动脉狭窄70%或更高的发生率分别为4%、20%、59%和17%。术后30天内有2例死亡(1.8%)。心肌梗死后早期接受手术的患者主动脉内球囊反搏的发生率较高(第一组为53%,第三组为22%)。统计学上,三组在使用正性肌力药物、心律失常的发生或术后心肌梗死方面无差异。所有患者(100%)均完成了后期随访(平均35个月,范围18至98个月)。有4例晚期心肌梗死和8例死亡。5年时的精算生存率为87%。108例患者中有73%无心绞痛,14%的病情有所改善。这些结果表明,心肌梗死后30天内进行心肌血运重建术的发病率和死亡率与药物治疗无效的慢性心绞痛择期手术相似。