Kim Eunwoo, Lee Hyun Young, Ye Young-Min, Kim Anhye
Department of Clinical Pharmacology & Therapeutics, CHA University Bundang Medical Center, Seongnam-si, Republic of Korea.
Department of Pharmacology, CHA University School of Medicine, Pocheon, Republic of Korea.
Clin Transl Sci. 2025 Jun;18(6):e70263. doi: 10.1111/cts.70263.
The corrected QT (QTc) interval is a critical marker for assessing proarrhythmic potential in drug development, while the corrected JT (JTc) interval provides specific insight into ventricular repolarization. This study quantitatively analyzed the relationships of QTc and JTc intervals with age and sex utilizing a large real-world dataset of hospital-based controls and moxifloxacin-treated patients. This retrospective study analyzed 1,039,550 electrocardiograms and associated clinical data extracted from a previously constructed electrocardiogram database, categorizing cases as hospital-based controls (n = 119,882) or moxifloxacin-treated (n = 1586) based on predefined criteria. We observed a general trend of QTc and JTc interval prolongation with age in both groups, with moxifloxacin-treated cases showing longer QTc and JTc intervals than hospital-based controls. Multiple linear regression analysis indicated that in hospital-based controls, QTc and JTc intervals increased with age, with males exhibiting shorter intervals than females. Meanwhile, in moxifloxacin-treated cases, QTc and JTc intervals showed similar age-dependent increases, although no significant sex differences were observed in the QTc interval. Therefore, this study quantified the effects of age and sex on QTc and JTc intervals in hospital-based controls and highlighted similar age-related trends in moxifloxacin-treated cases, underscoring the relevance of age and sex as key factors in interpreting QTc and JTc intervals across diverse clinical contexts.
校正QT（QTc）间期是药物研发中评估致心律失常潜力的关键指标，而校正JT（JTc）间期能为心室复极化提供具体见解。本研究利用一个基于医院对照和莫西沙星治疗患者的大型真实世界数据集，对QTc和JTc间期与年龄和性别的关系进行了定量分析。这项回顾性研究分析了从先前构建的心电图数据库中提取的1,039,550份心电图及相关临床数据，根据预定义标准将病例分类为医院对照（n = 119,882）或莫西沙星治疗组（n = 1586）。我们观察到两组中QTc和JTc间期均随年龄增长呈现总体延长趋势，莫西沙星治疗组的QTc和JTc间期比医院对照组更长。多元线性回归分析表明，在医院对照组中，QTc和JTc间期随年龄增加，男性的间期比女性短。同时，在莫西沙星治疗组中，QTc和JTc间期也呈现类似的年龄依赖性增加，尽管在QTc间期未观察到显著的性别差异。因此，本研究量化了年龄和性别对医院对照组QTc和JTc间期的影响，并突出了莫西沙星治疗组中类似的年龄相关趋势，强调了年龄和性别作为解释不同临床背景下QTc和JTc间期的关键因素的相关性。
