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Not a slam dunk (or Free Lunch): The complex future of Alzheimer's combination therapy.

作者信息

Sampaio Cristina

机构信息

CHDI Management, Inc. for CHDI Foundation, Princeton, USA; Professor Clinical Pharmacology, Faculdade de Medicina de Lisboa, Lisboa, Portugal.

出版信息

J Prev Alzheimers Dis. 2025 Jun;12(6):100211. doi: 10.1016/j.tjpad.2025.100211. Epub 2025 May 31.

DOI:10.1016/j.tjpad.2025.100211
PMID:40451697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12434263/
Abstract
摘要

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本文引用的文献

1
Challenges and opportunities for novel combination therapies in Alzheimer's disease: a report from the EU/US CTAD Task Force.阿尔茨海默病新型联合疗法的挑战与机遇：欧盟/美国CTAD特别工作组的报告
J Prev Alzheimers Dis. 2025 Jun;12(6):100163. doi: 10.1016/j.tjpad.2025.100163. Epub 2025 Apr 18.
2
Key considerations for combination therapy in Alzheimer's clinical trials: Perspectives from an expert advisory board convened by the Alzheimer's drug discovery foundation.阿尔茨海默病临床试验联合治疗的关键考量因素：来自阿尔茨海默病药物研发基金会召集的专家咨询委员会的观点
J Prev Alzheimers Dis. 2025 Jan;12(1):100001. doi: 10.1016/j.tjpad.2024.100001. Epub 2025 Jan 1.
3
Alzheimer's Disease: Combination Therapies and Clinical Trials for Combination Therapy Development.阿尔茨海默病：联合治疗以及用于联合治疗开发的临床试验。
CNS Drugs. 2024 Aug;38(8):613-624. doi: 10.1007/s40263-024-01103-1. Epub 2024 Jun 27.
4
Factors influencing prescribing the first add-on disease-modifying antirheumatic drugs in patients initiating methotrexate for rheumatoid arthritis.影响类风湿关节炎患者起始使用甲氨蝶呤时首次加用改善病情抗风湿药物处方的因素。
Explor Res Clin Soc Pharm. 2023 Jun 15;11:100296. doi: 10.1016/j.rcsop.2023.100296. eCollection 2023 Sep.
5
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.多奈哌齐治疗早期症状性阿尔茨海默病的随机临床试验。
JAMA. 2023 Aug 8;330(6):512-527. doi: 10.1001/jama.2023.13239.
6
Lecanemab in Early Alzheimer's Disease.早期阿尔茨海默病中的lecanemab
N Engl J Med. 2023 Jan 5;388(1):9-21. doi: 10.1056/NEJMoa2212948. Epub 2022 Nov 29.
7
Systematic Review of Real-World Treatment Patterns of Oral Antipsychotics and Associated Economic Burden in Patients with Schizophrenia in the United States.美国精神分裂症患者口服抗精神病药物的真实世界治疗模式及相关经济负担的系统评价
Adv Ther. 2022 Sep;39(9):3933-3956. doi: 10.1007/s12325-022-02232-z. Epub 2022 Jul 18.
8
The effect of newer antiepileptic drugs in combination therapy.
Epilepsy Res. 2017 May;132:15-20. doi: 10.1016/j.eplepsyres.2017.02.020. Epub 2017 Mar 2.