Galan J E, Timoney J F
J Immunol. 1985 Nov;135(5):3134-7.
Purpura hemorrhagica is an acute disease of the horse characterized by edema of the head and limbs, leucocytoclastic vasculitis, petechial hemorrhages in mucosae, musculature and viscera, and sometimes glomerulonephritis. It is usually associated with strangles, an upper respiratory tract disease of the horse caused by Streptococcus equi. We have detected and characterized immune complexes in the sera of horses with poststrangles purpura hemorrhagica by using PEG precipitation and Western blot analysis. The immune complexes contained IgA and S. equi-specific antigens similar to those found in acid extracts. We propose that purpura hemorrhagica is an immune complex-mediated disease.
出血性紫癜是马的一种急性疾病，其特征为头部和四肢水肿、白细胞破碎性血管炎、黏膜、肌肉组织和内脏出现瘀点性出血，有时还伴有肾小球肾炎。它通常与马腺疫有关，马腺疫是由马链球菌引起的马的一种上呼吸道疾病。我们通过聚乙二醇沉淀法和蛋白质印迹分析，检测并鉴定了患马腺疫后出血性紫癜马血清中的免疫复合物。这些免疫复合物含有与酸性提取物中发现的类似的IgA和马链球菌特异性抗原。我们认为出血性紫癜是一种免疫复合物介导的疾病。
