Uono Sanchez Alessandro, Saura Martins Altair Gustavo, Montebello Medeiros Bahé Ana Patricia, Oliveira Zucchi Francisco, Borges de Almeida Moacir Miguel, Vaz de Almeida Múcio Brandão, Mendes Heilmann Rodrigo, Cavalcanti Lucas Sabrina Giovana, Van der Linden Vanessa, Rolim Filho Epitácio Leite
Medical Science Center, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Association for Assistance of Disabled Children, Recife, Pernambuco, Brazil.
J Musculoskelet Neuronal Interact. 2025 Jun 1;25(2):172-177.
The objective of the present study was to assess gross motor function and describe musculoskeletal deformities in patients diagnosed with Congenital zika syndrome (CZS).
This is a cross-sectional study, carried out at the Association for Assistance of Disabled Children (AACD) in Pernambuco, Brazil, between June 2017 and April 2023. Medical records and assessments were carried out to describe musculoskeletal deformities and measure gross motor function, using the GMFM-88.
The study included 37 patients between 1 and 2 years old, 56.8% infected during the first trimester of pregnancy. The patients' mean GMFM value was 5.63 and standard deviation was 6.37. A moderate correlation was observed between head circumference at birth and the patients' current gross motor function (Pearson coeficient = 0.594) (p<0.001). We also observed 19 types of deformities, which were more prevalent in the lower limbs.
CZS brings significant impairments to motor function and the musculoskeletal system. In this context, measuring head circumference at birth can serve as a predictor of impaired gross motor function in these children.
本研究的目的是评估先天性寨卡综合征（CZS）患者的粗大运动功能，并描述其肌肉骨骼畸形情况。
这是一项横断面研究，于2017年6月至2023年4月在巴西伯南布哥州的残疾儿童援助协会（AACD）开展。通过病历和评估来描述肌肉骨骼畸形，并使用GMFM-88量表测量粗大运动功能。
该研究纳入了37名1至2岁的患者，其中56.8%在妊娠头三个月感染。患者的GMFM平均值得分为5.63，标准差为6.37。观察到出生时头围与患者当前的粗大运动功能之间存在中度相关性（皮尔逊系数=0.594）（p<0.001）。我们还观察到19种畸形类型，其中下肢更为常见。
先天性寨卡综合征给运动功能和肌肉骨骼系统带来了严重损害。在此背景下，出生时测量头围可作为这些儿童粗大运动功能受损的一个预测指标。
