Ley R D, Applegate L A
J Invest Dermatol. 1985 Oct;85(4):365-7. doi: 10.1111/1523-1747.ep12276992.
Induction of sunburn cells (SBCs) and hyperplasia of the epidermis of the marsupial Monodelphis domestica by ultraviolet radiation (UVR) has been studied. A dose of 500 J/m2 (approximately 1 minimal erythemal dose) from an FS-40 sunlamp induced measurable numbers of SBCs with a peak number at 32-48 h post-UVR exposure of skin to photoreactivating light suppressed the induction of SBCs by approximately 75%. Pre-UVR exposure to photoreactivating light had no effect on the induction of SBCs. Induction of hyperplasia also was suppressed to a similar extent by post-UVR photoreactivation treatment. These studies identify pyrimidine dimers in DNA as the major photoproduct involved in the induction of SBCs and hyperplasia in M. domestica by UVR.
对有袋动物家短尾负鼠的紫外线辐射（UVR）诱导晒伤细胞（SBCs）及表皮增生进行了研究。来自FS - 40太阳灯的500 J/m²剂量（约1个最小红斑剂量）可诱导出可测量数量的SBCs，在皮肤接受UVR照射后32 - 48小时达到峰值。对皮肤进行光复活处理可使SBCs的诱导数量减少约75%。UVR照射前进行光复活处理对SBCs的诱导没有影响。UVR照射后进行光复活处理也能将增生的诱导抑制到类似程度。这些研究确定DNA中的嘧啶二聚体是UVR诱导家短尾负鼠产生SBCs和增生的主要光产物。
