Ley R D, Applegate L A, Stuart T D, Fry R J
Biomedical Research Division, Lovelace Medical Foundation, Albuquerque, New Mexico.
Photodermatol. 1987 Jun;4(3):144-7.
Chronic exposure of the skin of the South American opossum (Monodelphis domestica) to ultraviolet radiation (UVR) from an FS-40 sunlamp (280-400 nm) 3 times per week for a total of 200 exposures resulted in the appearance of actinic keratoses, fibrosarcomas, squamous cell carcinomas and keratoacanthomas. At the higher doses of UVR used in this study, moderate to severe hyperplasia was also observed. The susceptibility of this animal to the induction of skin tumors by UVR in conjunction with the capacity to enzymatically photoreactive pyrimidine dimers in cutaneous DNA identifies this animal as a useful model in determining the role of pyrimidine dimers in skin tumor induction by UVR.
每周三次，将南美负鼠（Monodelphis domestica）的皮肤长期暴露于FS - 40太阳灯发出的紫外线辐射（UVR，280 - 400纳米）下，共进行200次照射，结果出现了光化性角化病、纤维肉瘤、鳞状细胞癌和角化棘皮瘤。在本研究中使用的较高UVR剂量下，还观察到中度至重度增生。这种动物对UVR诱导皮肤肿瘤的易感性，以及其对皮肤DNA中嘧啶二聚体进行酶促光反应的能力，使得这种动物成为确定嘧啶二聚体在UVR诱导皮肤肿瘤中作用的有用模型。
