Sidler Melanie, Brugger Daniel, Riond Barbara, Dennler Matthias, Unterer Stefan, Kook Peter H
Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Institute for Animal Nutrition and Dietetics, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
J Vet Intern Med. 2025 Jul-Aug;39(4):e70134. doi: 10.1111/jvim.70134.
It is unclear if dogs with acute pancreatitis differ clinically from dogs with non-pancreatic acute gastrointestinal disease (aGId).
Compare clinical findings in dogs with acute gastrointestinal signs suspected of having acute pancreatitis (sAP) based on increased DGGR-lipase activity versus those with presumptive aGId.
Twenty-six dogs with sAP, 48 dogs with aGId based on acute signs, lipase activity > 450 U/L (RI, 17-156 U/L) and within/minimally (20 U/L) > RI, respectively.
Prospective study. Clinical signs were graded using a simplified modified clinical activity index (MCAI). CBC, biochemistry, C-reactive protein (CRP), pancreatic, and gastrointestinal ultrasonographic findings were compared between groups.
Median (range) disease duration before presentation (sAP 36 h [3-96 h], aGId 48 h [3-168 h]) did not differ. Diarrhea was significantly more frequent in aGId; MCAI did not differ between groups. Median (range) lipase activities in sAP and aGId dogs were 1280 U/L (451-6712) and 49.5 U/L (14-176), respectively. Alkaline phosphatase activity and bilirubin were significantly higher in sAP. Pancreatic ultrasonographic abnormalities were significantly more common in sAP. In aGId, a mixed-echoic (17/44, 39%), hyperechoic (9/44, 20%), hypoechoic pancreas (3/44, 7%), and hyperechoic mesentery (4/44, 9%) were found. Only a distended stomach was significantly more common in sAP. Multivariable logistic regression analysis only identified pancreatic enlargement and ultrasonographic diagnosis of pancreatitis to increase the odds of sAP. Hospitalization (median, range) did not differ (sAP 3, 1-8 days; aGId 2.5, 1-5 days).
Both groups do not differ in clinical severity; diarrhea is less prevalent, and mild cholestasis is more common in sAP. Pancreatic ultrasonographic changes suggestive of AP are rare in aGId.
患有急性胰腺炎的犬在临床上是否与患有非胰腺急性胃肠疾病（aGId）的犬不同尚不清楚。
比较基于犬胰脂肪酶（DGGR）活性升高而疑似患有急性胰腺炎（sAP）的急性胃肠道症状犬与推定患有aGId的犬的临床发现。
26只患有sAP的犬，48只基于急性症状、脂肪酶活性分别>450 U/L（参考区间，17 - 156 U/L）和在参考区间内/略高于参考区间（20 U/L）而患有aGId的犬。
前瞻性研究。使用简化的改良临床活动指数（MCAI）对临床症状进行分级。比较两组之间的血常规、生化、C反应蛋白（CRP）、胰腺和胃肠道超声检查结果。
就诊前疾病持续时间的中位数（范围）（sAP为36小时[3 - 96小时]，aGId为48小时[3 - 168小时]）无差异。腹泻在aGId中明显更常见；两组之间MCAI无差异。sAP和aGId犬的脂肪酶活性中位数（范围）分别为1280 U/L（451 - 6712）和49.5 U/L（14 - 176）。sAP中的碱性磷酸酶活性和胆红素明显更高。胰腺超声检查异常在sAP中明显更常见。在aGId中，发现混合回声（17/44，39%）、高回声（9/44，20%）、低回声胰腺（3/44，7%）和高回声肠系膜（4/44，9%）。仅胃扩张在sAP中明显更常见。多变量逻辑回归分析仅确定胰腺肿大和胰腺炎的超声诊断会增加sAP的几率。住院时间（中位数，范围）无差异（sAP为3天，1 - 8天；aGId为2.5天，1 - 5天）。
两组在临床严重程度上无差异；腹泻在sAP中不太常见，轻度胆汁淤积在sAP中更常见。提示急性胰腺炎（AP）的胰腺超声改变在aGId中很少见。
