Grundin T G, Roomans G M, Forslind B, Lindberg M, Werner Y
J Invest Dermatol. 1985 Oct;85(4):378-80. doi: 10.1111/1523-1747.ep12277009.
Electron probe x-ray microanalysis was used to study elemental distribution in uninvolved and involved skin from patients with psoriasis, and in skin from healthy controls. Significant differences were found between the involved and uninvolved psoriatic skin. In the involved skin, the concentrations of Mg, P, and K were higher in the stratum germinativum, spinosum, and granulosum, compared to the corresponding strata in uninvolved skin. Neither involved nor uninvolved psoriatic stratum germinativum differed markedly from nonpsoriatic control stratum germinativum. In uninvolved psoriatic skin only a lower level of K was noted. In comparison to uninvolved psoriatic skin, the elemental composition of the various strata of involved psoriatic skin shows a pattern typical for highly proliferative, nonneoplastic cells.
采用电子探针X射线微量分析技术研究银屑病患者未受累皮肤和受累皮肤以及健康对照者皮肤中的元素分布。发现银屑病受累皮肤和未受累皮肤之间存在显著差异。在受累皮肤中，与未受累皮肤的相应层相比，基底层、棘层和颗粒层中的镁、磷和钾浓度更高。银屑病受累和未受累的基底层与非银屑病对照基底层均无明显差异。在未受累的银屑病皮肤中，仅发现钾含量较低。与未受累的银屑病皮肤相比，受累的银屑病皮肤各层的元素组成显示出高度增殖的非肿瘤细胞的典型模式。
