Cho Minkyoung, Yu Hak Sun
Department of Parasitology and Tropical Medicine, Institute of Medical Science, College of Medicine, Gyeongsang National University, Jinju 52727, Korea.
Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Parasites Hosts Dis. 2025 May;63(2):123-134. doi: 10.3347/PHD.24086. Epub 2025 May 26.
The incidence of immune system diseases is increasing globally, particularly in developed countries. The hygiene and old friend hypotheses suggest that the decreased incidence of helminth infections in these countries may underlie the rising prevalence of autoimmune, allergic, and inflammatory diseases. The preventive and therapeutic potential of Trichinella spiralis, a helminthic parasite, has been well demonstrated in animal models of immune dysregulation-mediated diseases. This review comprehensively analyze how T. spiralis modulates immune responses across a spectrum of immune dysregulation. We systematically review the key research findings on the effects of T. spiralis infection on immune-related disease. T. spiralis has shown the ability to regulate host immune responses in autoimmune, allergic, and inflammatory disorders, exerting anti-inflammatory effects and restoring immune homeostasis through various immunological pathways. Given its significant immunomodulatory potential, T. spiralis represents a promising candidate for therapeutic interventions against immune-mediated diseases, warranting further molecular investigations and clinical applications.
全球范围内，免疫系统疾病的发病率正在上升，尤其是在发达国家。卫生假说和老朋友假说表明，这些国家蠕虫感染发病率的下降可能是自身免疫性、过敏性和炎症性疾病患病率上升的原因。旋毛虫作为一种寄生虫，其预防和治疗潜力在免疫失调介导疾病的动物模型中已得到充分证明。这篇综述全面分析了旋毛虫如何在一系列免疫失调中调节免疫反应。我们系统地回顾了关于旋毛虫感染对免疫相关疾病影响的关键研究结果。旋毛虫已显示出在自身免疫性、过敏性和炎症性疾病中调节宿主免疫反应的能力，通过各种免疫途径发挥抗炎作用并恢复免疫稳态。鉴于其显著的免疫调节潜力，旋毛虫是免疫介导疾病治疗干预的一个有前途的候选者，值得进一步的分子研究和临床应用。
