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Low rates of endothelial cell dysfunction and transplant-related mortality in 537 children receiving fludarabine-treosulfan conditioning for all transplant indications: A retrospective multicentre study on behalf of the UK Paediatric BMT group.

作者信息

Altmann Thomas, Rao Kanchan, Hanasoge-Nataraj Ramya, Patrick Katharine, Carpenter Ben, Hough Rachael, Ewins Anna-Maria, Tewari Sanjay, Mirci-Danicar Oana, Slatter Mary, Wynn Robert, Lum Su Han

机构信息

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Paediatric Immunology, Great North Children's Hospital, Newcastle upon Tyne, UK.

出版信息

Br J Haematol. 2025 Jun 1;207(2):631-5. doi: 10.1111/bjh.20184.

DOI:10.1111/bjh.20184
PMID:40452282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12378902/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cd/12378902/009a6aeffb93/BJH-207-631-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cd/12378902/009a6aeffb93/BJH-207-631-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cd/12378902/009a6aeffb93/BJH-207-631-g001.jpg

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Low rates of endothelial cell dysfunction and transplant-related mortality in 537 children receiving fludarabine-treosulfan conditioning for all transplant indications: A retrospective multicentre study on behalf of the UK Paediatric BMT group.537名接受氟达拉滨-苏消安预处理以适应所有移植适应症的儿童内皮细胞功能障碍发生率和移植相关死亡率较低：一项代表英国儿科骨髓移植组开展的回顾性多中心研究。
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本文引用的文献

1
Treosulfan vs busulfan conditioning for allogeneic bmt in children with nonmalignant disease: a randomized phase 2 trial.三嗪类药物（曲奥舒凡）与马利兰（白消安）预处理方案用于儿童非恶性疾病异基因造血干细胞移植的随机 2 期临床试验。
Bone Marrow Transplant. 2024 Jan;59(1):107-116. doi: 10.1038/s41409-023-02135-9. Epub 2023 Nov 4.
2
Effect of Busulfan and Treosulfan on Gonadal Function after Allogeneic Stem Cell Transplantation in Children and Adolescents with Nonmalignant Diseases Is Not Exposure-Dependent.硼替佐米、沙利度胺联合地塞米松方案治疗多发性骨髓瘤的疗效及安全性 硼替佐米、沙利度胺联合地塞米松方案治疗多发性骨髓瘤的疗效及安全性 硼替佐米、沙利度胺联合地塞米松方案治疗多发性骨髓瘤的疗效及安全性
Transplant Cell Ther. 2023 Aug;29(8):529.e1-529.e5. doi: 10.1016/j.jtct.2023.05.003. Epub 2023 May 6.
3
A retrospective study of treosulfan versus busulfan-based conditioning in pediatric patients.一项关于小儿患者中曲奥舒凡与白消安预处理方案的回顾性研究。
Eur J Haematol. 2022 Nov;109(5):474-482. doi: 10.1111/ejh.13828. Epub 2022 Jul 21.
4
Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis.Wiskott-Aldrich 综合征的造血干细胞移植：EBMT 先天性错误工作组分析。
Blood. 2022 Mar 31;139(13):2066-2079. doi: 10.1182/blood.2021014687.
5
Association Between the Magnitude of Intravenous Busulfan Exposure and Development of Hepatic Veno-Occlusive Disease in Children and Young Adults Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation.静脉注射白消安暴露程度与接受清髓性异基因造血细胞移植的儿童和青年成人肝静脉闭塞病发展的相关性。
Transplant Cell Ther. 2022 Apr;28(4):196-202. doi: 10.1016/j.jtct.2022.01.013. Epub 2022 Jan 19.
6
Busulfan-fludarabine- or treosulfan-fludarabine-based myeloablative conditioning for children with thalassemia major.以白消安-氟达拉滨或三氧化二砷-氟达拉滨为基础的骨髓清除性预处理方案治疗重型地中海贫血患儿。
Ann Hematol. 2022 Mar;101(3):655-665. doi: 10.1007/s00277-021-04732-4. Epub 2022 Jan 9.
7
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Transplant Cell Ther. 2022 Feb;28(2):99.e1-99.e7. doi: 10.1016/j.jtct.2021.09.018. Epub 2021 Oct 1.
8
Long-Term Outcomes of Treosulfan- vs. Busulfan-Based Conditioning Regimen for Patients With Myelodysplastic Syndrome and Acute Myeloid Leukemia Before Hematopoietic Cell Transplantation: A Systematic Review and Meta-Analysis.造血细胞移植前，采用曲奥舒凡与白消安为基础的预处理方案治疗骨髓增生异常综合征和急性髓系白血病患者的长期预后：一项系统评价和荟萃分析
Front Oncol. 2020 Dec 16;10:591363. doi: 10.3389/fonc.2020.591363. eCollection 2020.
9
Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults.慢性肉芽肿病的造血细胞移植：712例儿童和成人的研究
Blood. 2020 Sep 3;136(10):1201-1211. doi: 10.1182/blood.2020005590.
10
Treosulfan-fludarabine-thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies.三氧化二砷-氟达拉滨-噻替哌预处理方案在异基因造血干细胞移植治疗儿童血液系统恶性肿瘤中的应用。
Bone Marrow Transplant. 2020 Oct;55(10):1996-2007. doi: 10.1038/s41409-020-0869-6. Epub 2020 Mar 20.