Yilmaz Deniz, Akkaya Eyyup
Department of Internal Diseases, University of Health Sciences Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkiye.
Department of Hematology, University of Health Sciences Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkiye.
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251347630. doi: 10.1177/10760296251347630. Epub 2025 Jun 2.
This study aimed to assess the utility of the hematocrit-to-hemoglobin ratio (HHR) and the HALP score in detecting thrombosis history in patients with polycythemia vera (PV). This retrospective study examined patients diagnosed with PV between January 2013 and December 2022. Demographics, clinical history, PV- and thrombosis-related data, laboratory findings, follow-up duration, and mortality status were retrieved from hospital records. HHR and HALP scores were calculated for all patients. Patients were grouped based on their thrombosis history. A total of 124 PV patients were included, with a mean age of 57.65 ± 12.17 years, and 86 (69.35%) were males. Thrombosis was present in 59 patients (47.58%), with 32.20% occurring before diagnosis, 23.73% at diagnosis, and 44.07% after diagnosis. Patients with and without thrombosis history were similar in age and sex. Those with a history of thrombosis had significantly higher anticoagulant use and HHR values, while other variables, including HALP score, showed no differences. An HHR cut-off value of >3.05 predicted thrombosis history with 54.24% sensitivity and 72.31% specificity. HHR could help distinguish PV patients with thrombosis history, though its sensitivity is low. HALP score was not associated with thrombosis risk.
本研究旨在评估血细胞比容与血红蛋白比值（HHR）和HALP评分在检测真性红细胞增多症（PV）患者血栓形成史方面的效用。这项回顾性研究对2013年1月至2022年12月期间诊断为PV的患者进行了检查。从医院记录中获取了人口统计学、临床病史、PV和血栓形成相关数据、实验室检查结果、随访时间和死亡状态。计算了所有患者的HHR和HALP评分。根据患者的血栓形成史进行分组。共纳入124例PV患者，平均年龄为57.65±12.17岁，其中86例（69.35%）为男性。59例患者（47.58%）出现血栓形成，其中32.20%发生在诊断前，23.73%发生在诊断时，44.07%发生在诊断后。有和没有血栓形成史的患者在年龄和性别方面相似。有血栓形成史的患者抗凝药物使用和HHR值显著更高，而其他变量，包括HALP评分，无差异。HHR临界值>3.05预测血栓形成史的敏感性为54.24%，特异性为72.31%。HHR有助于区分有血栓形成史的PV患者，尽管其敏感性较低。HALP评分与血栓形成风险无关。
