Chen Guorong, Bao Bahu, Ye Yucai, Hu Aoyan, Sun Jingzi, Liu Weiying
Department of Respiratory Medicine, The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Department of Respiratory and Critical Care Medicine, the First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Front Oncol. 2025 May 16;15:1532343. doi: 10.3389/fonc.2025.1532343. eCollection 2025.
Although the systemic immune-inflammation index (SII) has emerged as a potential prognostic marker in various cancers, its specific role in non-small cell lung cancer (NSCLC) patients undergoing immunotherapy remains insufficiently explored. To address this critical gap, we conducted a comprehensive meta-analysis to assess the prognostic value of SII in NSCLC patients treated with immune checkpoint inhibitors (ICIs).
A comprehensive search was conducted across multiple databases-including PubMed, EMBASE, Cochrane and Web of Science-to identify relevant studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled to evaluate the prognostic significance of SII for survival outcomes.
Ten studies involving a total of 1,547 patients were included. High systemic immune-inflammation index (SII) was significantly associated with worse overall survival (OS) (HR=1.44, 95% CI=1.21-1.70, p < 0.001; I²=3.8%) and progression-free survival (PFS) (HR=1.44, 95% CI=1.21-1.71, p < 0.001; I²=37.2%). Subgroup analysis indicated that an SII >792 was significantly associated with poorer OS and PFS.
High SII is significantly associated with poorer OS and PFS, particularly when SII >792.
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024586791, identifier RD42024586791.
尽管全身免疫炎症指数（SII）已成为各种癌症潜在的预后标志物，但其在接受免疫治疗的非小细胞肺癌（NSCLC）患者中的具体作用仍未得到充分探索。为了填补这一关键空白，我们进行了一项全面的荟萃分析，以评估SII在接受免疫检查点抑制剂（ICI）治疗的NSCLC患者中的预后价值。
在多个数据库（包括PubMed、EMBASE、Cochrane和Web of Science）中进行全面检索，以识别相关研究。汇总风险比（HR）和95%置信区间（CI），以评估SII对生存结局的预后意义。
纳入了10项研究，共1547例患者。高全身免疫炎症指数（SII）与较差的总生存期（OS）（HR=1.44，95%CI=1.21-1.70，p<0.001；I²=3.8%）和无进展生存期（PFS）（HR=1.44，95%CI=1.21-1.71，p<0.001；I²=37.2%）显著相关。亚组分析表明，SII>792与较差的OS和PFS显著相关。
高SII与较差的OS和PFS显著相关，尤其是当SII>792时。
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024586791，标识符RD42024586791。
