Wang Chen, Zhou Lijie, Wang Yangang
The Third Clinical Medical College of Beijing University of Chinese Medicine, Beijing, China.
The Department of Spleen and Stomach, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
Front Oncol. 2025 May 16;15:1556009. doi: 10.3389/fonc.2025.1556009. eCollection 2025.
Gastric stem cells (GSCs) and chief cells are vital for maintaining gastric epithelial homeostasis. However, under pathological conditions, these cells undergo significant functional changes, contributing to the progression of precancerous lesions of gastric cancer (PLGC). Dysregulation of key signaling pathways such as WNT, NF-κB, and YAP leads to aberrant cellular behaviors, which are implicated in the early stages of gastric carcinogenesis. This study aimed to elucidate the roles of GSCs and chief cells in maintaining gastric epithelial integrity, their contributions to the development of precancerous lesions, and the molecular mechanisms that regulate their behavior during disease progression.
The study integrated bibliometric analysis, pathfinding, and data visualization using tools such as CiteSpace, VOSviewer, and R software. Functional enrichment of target genes was analyzed using KEGG and GO databases. The study focused on gastric cell changes, including differentiation, dedifferentiation, and signaling pathway activation, within the context of GSC and chief cell plasticity. Molecular markers and pathway-specific mechanisms were analyzed to clarify their contributions to gastric precancerous lesions.
Data from the WoSCC database from 2004 to 2024 showed a steady increase in publications on "PLGC-gastric stem cells" and "PLGC-chief cells," with the United States, China, and Japan leading in publication volume. International cooperation was evident, particularly with Canada playing a central role in academic exchanges. Key terms included stem cells, intestinal chemotaxis, and cancer, with recent focus on spasmolytic polypeptide-expressing metaplasia.
The dynamic interactions between GSCs and chief cells are fundamental to gastric homeostasis and disease progression. GSCs primarily drive chronic inflammation-induced metaplasia and dysplastic changes, while chief cells facilitate acute epithelial repair through dedifferentiation. These findings highlight potential therapeutic targets and emphasize the importance of regulating dysregulated pathways to prevent gastric cancer. The research results will guide future studies in the fields of "PLGC-gastric stem cells" and "PLGC-chief cells," focusing on the spatiotemporal dynamics of each cell type under various injury and inflammatory conditions, as well as identifying early biomarkers of cellular changes for timely intervention.
胃干细胞（GSCs）和主细胞对于维持胃上皮内环境稳定至关重要。然而，在病理条件下，这些细胞会发生显著的功能变化，促使胃癌癌前病变（PLGC）进展。关键信号通路如WNT、NF-κB和YAP的失调会导致异常的细胞行为，这与胃癌发生的早期阶段有关。本研究旨在阐明胃干细胞和主细胞在维持胃上皮完整性中的作用、它们对癌前病变发展的贡献以及在疾病进展过程中调节其行为的分子机制。
本研究使用CiteSpace、VOSviewer和R软件等工具，整合了文献计量分析、路径查找和数据可视化。使用KEGG和GO数据库分析靶基因的功能富集。该研究聚焦于胃干细胞和主细胞可塑性背景下的胃细胞变化，包括分化、去分化和信号通路激活。分析分子标志物和通路特异性机制，以阐明它们对胃癌前病变的贡献。
来自2004年至2024年WoSCC数据库的数据显示，关于“PLGC - 胃干细胞”和“PLGC - 主细胞”的出版物稳步增加，美国、中国和日本的出版物数量领先。国际合作明显，特别是加拿大在学术交流中发挥核心作用。关键术语包括干细胞、肠道趋化性和癌症，近期重点是表达解痉多肽化生。
胃干细胞和主细胞之间的动态相互作用对于胃内环境稳定和疾病进展至关重要。胃干细胞主要驱动慢性炎症诱导的化生和发育异常变化，而主细胞通过去分化促进急性上皮修复。这些发现突出了潜在的治疗靶点，并强调了调节失调通路以预防胃癌的重要性。研究结果将指导未来在“PLGC - 胃干细胞”和“PLGC - 主细胞”领域的研究，重点关注每种细胞类型在各种损伤和炎症条件下的时空动态，以及识别细胞变化的早期生物标志物以便及时干预。
