Jiang Chuhan, Xin Huizhen, Liu Yuhang, Han Yangyang
Department of Biology, School of Basic Medical Sciences Xinjiang Medical University, Urumqi, China.
Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi, China.
Front Oncol. 2025 May 16;15:1566986. doi: 10.3389/fonc.2025.1566986. eCollection 2025.
Cuproptosis is a new form of cell death induced by intracellular copper overload. With the deepening of research, the research of cuproptosis in the field of cancer has become a hot topic. The bibliometric analysis of cuproptosis research can provide valuable insights into the development of this field.
In this study, the Web of Science Core Collection database was used to obtain literature, and the screened data were imported into CiteSpace software for analysis. We use this data for visualization analysis and made knowledge maps including authors, countries, institutions, journals, and keywords.
1140 literature was obtained from Web of Science from 2001 to 2024. The results indicate a consistent upward trend in the number of publications in this field. Moreover, a particularly significant surge in the frequency of citations has been observed since 2022. Through a systematic analysis, we found that in the current field of cancer research on cuproptosis, breast cancer, lung cancer, hepatocellular carcinoma and colorectal cancer have more research results.
This article describes how copper ions regulate cell death, particularly in cancer therapy, and requires an in-depth understanding of the complexity of copper metabolism and its specific mechanisms of action in cell death. The work provides a panoramic view of the research landscape on cuproptosis in cancer, highlighting its potential as a therapeutic target and the need for further exploration into its mechanisms and clinical applications. With the depth of research, it is expected that cuproptosis will continue to be a hotspot in cancer treatment research. In addition, it provides a solid theoretical foundation and experimental basis for the development of new anti-tumor therapeutic strategies.
铜死亡是一种由细胞内铜过载诱导的新型细胞死亡形式。随着研究的深入，铜死亡在癌症领域的研究已成为热门话题。对铜死亡研究的文献计量分析可为该领域的发展提供有价值的见解。
本研究利用科学网核心合集数据库获取文献，并将筛选后的数据导入CiteSpace软件进行分析。我们使用这些数据进行可视化分析，并制作了包括作者、国家、机构、期刊和关键词在内的知识图谱。
从科学网获取了2001年至2024年的1140篇文献。结果表明该领域的出版物数量呈持续上升趋势。此外，自2022年以来，引文频次出现了特别显著的激增。通过系统分析，我们发现，在当前癌症铜死亡研究领域，乳腺癌、肺癌、肝细胞癌和结直肠癌的研究成果较多。
本文描述了铜离子如何调节细胞死亡，特别是在癌症治疗中，并需要深入了解铜代谢的复杂性及其在细胞死亡中的具体作用机制。这项工作提供了癌症铜死亡研究领域的全景图，突出了其作为治疗靶点的潜力以及进一步探索其机制和临床应用的必要性。随着研究的深入，预计铜死亡将继续成为癌症治疗研究的热点。此外，它为开发新的抗肿瘤治疗策略提供了坚实的理论基础和实验依据。
