Chen Chris Xie, Li Shirley Xin, Ho Chung Shun, Chan Joey Wing Yan, Chan Leo King Wai, Lee Tatia Mei-Chun, Wing Yun Kwok, Chan Ngan Yin
Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Sleep Research Clinic and Laboratory, Department of Psychology, The University of Hong Kong, Hong Kong SAR, China.
Int J Clin Health Psychol. 2025 Apr-Jun;25(2):100570. doi: 10.1016/j.ijchp.2025.100570. Epub 2025 May 2.
Previous evidence suggest that sleep contributed to resilience. However, specific sleep markers for resilience in adolescents remain unknown. This study aimed to examine the associations between macro- and microstructures of sleep with resilience in healthy adolescents. This study hypothesized that specific features of both NREM and REM sleep were associated with resilience in healthy adolescents.
Forty-two healthy adolescents (Mean age: 15.98 years, SD: 2.16 years; female: 57.1 %) were included in this study. Adolescents with any diagnosed sleep or psychiatric disorders were excluded. Participants completed questionnaires that assessed resilience capacity and outcome, childhood trauma, and mental well-being, and underwent polysomnography. Resilience capacity was defined using the score of the Resilience Scale for Chinese Adolescents (RSCA). Resilience outcome was calculated by the residual approach in a linear model using mental well-being (KIDSCREEN) as dependent variable and childhood trauma (Childhood Trauma Questionnaire) as independent variable. NREM and REM sleep macrostructures and microstructures were calculated.
The results showed that higher fast beta power (24-32 Hz) in REM sleep and longer spindle duration in NREM sleep were significantly associated with higher resilience capacity. However, slow wave sleep properties were not associated with either resilience capacity or resilience outcome. In addition, macrostructures of sleep did not differ across resilience groups.
The findings suggest that microstructures of both REM and NREM sleep could serve as biomarkers for resilience. This study could potentially pave the way for prevention and intervention strategies of stress-related disorders in adolescents.
先前的证据表明睡眠有助于恢复力。然而，青少年恢复力的具体睡眠标志物仍不明确。本研究旨在探讨健康青少年睡眠的宏观和微观结构与恢复力之间的关联。本研究假设非快速眼动（NREM）睡眠和快速眼动（REM）睡眠的特定特征均与健康青少年的恢复力相关。
本研究纳入了42名健康青少年（平均年龄：15.98岁，标准差：2.16岁；女性：57.1%）。排除任何已诊断出睡眠或精神障碍的青少年。参与者完成了评估恢复力能力和结果、童年创伤及心理健康的问卷，并接受了多导睡眠监测。恢复力能力采用中国青少年恢复力量表（RSCA）评分进行定义。恢复力结果通过线性模型中的残差法计算，以心理健康（儿童生活质量量表）为因变量，童年创伤（儿童创伤问卷）为自变量。计算NREM睡眠和REM睡眠的宏观结构和微观结构。
结果显示，REM睡眠中较高的快β波功率（24 - 32赫兹）和NREM睡眠中较长的纺锤波持续时间与较高的恢复力能力显著相关。然而，慢波睡眠特征与恢复力能力或恢复力结果均无关联。此外，不同恢复力组之间的睡眠宏观结构没有差异。
研究结果表明，REM睡眠和NREM睡眠的微观结构均可作为恢复力的生物标志物。本研究可能为青少年应激相关障碍的预防和干预策略铺平道路。
