Zhang Xinyu, Yang Jie, Li Yilin, Li Yulin, Li Guoqi
Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.
PeerJ. 2025 May 29;13:e19532. doi: 10.7717/peerj.19532. eCollection 2025.
The hypothalamus, a crucial neuroendocrine regulatory center, plays a significant role in the occurrence and development of metabolic diseases. Recent advances in molecular biology and imaging technology have facilitated a better understanding of the central role of the hypothalamus in the dysregulation of regulatory mechanisms. This review examines the involvement of hypothalamic nuclei in metabolic diseases, the direct effects of glucose and fat on the hypothalamus, and the influence of the hypothalamus on metabolic diseases. Furthermore, it investigates the role of the hypothalamus in the emergence and progression of metabolic disorders, including obesity and diabetes. Finally, it outlines the current research progress in treating metabolic diseases through hypothalamus regulation. This study could provide a theoretical basis for understanding the pathophysiological mechanisms of metabolic diseases and development of new treatment strategies.
下丘脑作为一个关键的神经内分泌调节中心，在代谢性疾病的发生和发展中起着重要作用。分子生物学和成像技术的最新进展有助于更好地理解下丘脑在调节机制失调中的核心作用。本综述探讨了下丘脑核团在代谢性疾病中的参与情况、葡萄糖和脂肪对下丘脑的直接影响，以及下丘脑对代谢性疾病的影响。此外，还研究了下丘脑在代谢紊乱（包括肥胖和糖尿病）的发生和发展中的作用。最后，概述了通过下丘脑调节治疗代谢性疾病的当前研究进展。这项研究可为理解代谢性疾病的病理生理机制和开发新的治疗策略提供理论基础。
