This review examines the current research progress of molecular agriculture for cytokine expression, the research status of keratinocyte growth factor-2 (KGF-2) for skin care, hair growth, and the research status of plants for hair growth. KGF-2 application and use are inhibited by factors, such as the cost of production and efficacy due to low transdermal penetration potential. However, cell penetrating peptides (CPPs) are powerful transporter tools that assist the transmembrane delivery of attached biomacromolecules. Biomacromolecules such as KGF-2 have poor transdermal ability, which can be enhanced by combining with CPP such as TD1 to construct fusion proteins. has many advantages, such as short growth cycle, high transformation efficiency, large biomass and hair growth promotion substances. Therefore, we also discuss the feasibility and expression strategies of using plant system to express fusion protein TDP1-KGF-2, which provides new idea for enhancing the transdermal ability of KGF-2 and providing new idea for plant system expression of fusion protein. This offers a promising new direction for the development of natural hair care and hair growth materials, as well as innovative possibilities for the application of molecular agriculture.